氟哌噻吨美利曲辛治疗氯胺酮依赖者焦虑抑郁的疗效观察  

Clinical observation of the curative effects of flupentixol and melitracen on anxiety and depression in patients with ketamine dependence

作　　者：桂冬辉[1] 蔡丹丹[1] 张建兵[1] 黄燕燕[1] 周文华[1] 

机构地区：[1]宁波戒毒研究中心,宁波315010

出　　处：《中国临床药学杂志》2014年第3期137-140,共4页Chinese Journal of Clinical Pharmacy

基　　金：科技部"十二五"支撑项目(编号2012BA101B07)

摘　　要：目的探讨氟哌噻吨美利曲辛治疗氯胺酮依赖者焦虑抑郁的临床疗效和安全性。方法将60例氯胺酮依赖者随机分成2组。研究组30例，予氟哌噻吨美利曲辛治疗（日剂量2～3片，bid）；对照组30例，予劳拉西泮治疗（日剂量2～4mg，bid）。疗程均为6周。于治疗前及治疗1、2、4、6周末，采用汉密尔顿焦虑量表（HAMA）和汉密尔顿抑郁量表（HAMD）进行疗效评定，用不良反应量表（TESS）和实验室检查评定安全性。结果两组6周末共脱落12例，余48例完成6周治疗。两组内HAMA、HAMD评分比较差异均有统计学意义（P〈0．05或P〈0．01）。两组间6周末比较，HAMA评分研究组和对照组分别为8．44±2．12和9．26±2．07，差异无统计学意义（P〉0．05）；HAMD评分研究组和对照组分别为9．36±2．00和11．06±2．71，差异有统计学意义（P〈0．05或P〈0．01）。两组临床疗效比较，研究组有效率为80％，对照组有效率为43％，差异有统计学意义（P〈0．05）。结论氟哌噻吨美利曲辛能够显著改善氯胺酮依赖者的焦虑抑郁情绪，安全性和耐受性较好，且无潜在药物依赖性。AIM To investigate the clinical efficacy and safety of flupentixol and melitracen in treatment of anxiety and depression disorders with ketamine addicts. METHORDS Sixty patients were randomly divided into 2 groups. Thirty patients of the study group were given flupentixol and melitracen and 30 patients of the control group were given lorazepam, respectively. Hamilton Anxiety Scale（HAMA） and Hamilton Depression Scale （HAMD） were used to evaluate the efficacy before treatment and at 1,2,4,6 weeks after the treatment. The safety was evaluated with Treatment Emergent Side-Effect Scale （TESS） and laboratory tests. RESULTS Twelve patients were fellen off after 6 weeks, and 48 patients completed the course of treatment. There were significant differences in HAMA and HAMD scores in 2 groups （P 〈 0.05 or P 〈 0.01）. The comparison between 2 groups at 6 weeks was as belows：the HAMA scores of the study group and the control group were 8.44 ±2.12 and 9.26 ±2.07 respectively, the difference was not statistically significant （ P 〉 0.05） ,and the HAMD scores of the study group and the control group were 9.36 ±2.00 and 11.06 ±2.71 respectively, the difference was statistically significant（ P 〈 0.05）. The effective rate in the study group was 80% , higher than that of the control group of 43 %, which of the 2 groups had significant difference（ P 〈 0.05）. CONCLUSION Flupentixol and melitraeen achieves the definite efficacy on ketamine dependence via improving the depression and anxiety. The treatment is safe, well tolerant, and has low risk of drug dependence.

关 键 词：氟哌噻吨美利曲辛 劳拉西泮 氯胺酮依赖 焦虑 抑郁 疗效 

分 类 号：R749.61[医药卫生—神经病学与精神病学]