卡泊三醇联合窄谱紫外线治疗掌跖脓疱病疗效观察  

Clinical Effect of Calcipotriol Combined with Narrow-Band Ultraviolet for the Treatment of Palmoplantar Pustulosis

作　　者：孙婷[1] 晏洪波[1] 吴宁[1] 

机构地区：[1]广州军区武汉总医院皮肤科,湖北武汉430070

出　　处：《武汉大学学报（医学版）》2014年第3期474-476,共3页Medical Journal of Wuhan University

摘　　要：目的:研究卡泊三醇联合窄谱紫外线治疗掌跖脓疱病的效果。方法:以2011年3月-2012年8月我院收治的41例掌跖脓疱病为研究对象。所有患者随机分为2组:观察组共23人,给予卡泊三醇软膏外用联合窄谱紫外线治疗;对照组19人,单纯给予卡泊三醇软膏外用。疗程4周。治疗期间及治疗后定期观察,记录两组患者不良反应,并比较疗效。结果:治疗4周,观察组和对照组总有效率分别为91.3%和78.9%,两组比较,差异有统计学意义(P<0.05)。在治疗过程中两组均有不良事件发生,但是症状轻微,不影响继续治疗。结论:卡泊三醇联合窄谱紫外线治疗掌跖脓疱病安全有效,值得在临床应用推广。Objective：To investigate the clinical effect of caleipotriol combined with narrow-band ultravi- olet for the treatment of palmoplantar pustulosis. Methods： In the present study, 41 patients with palmoplantar pustulosis in our hospital from March 2011 to August 2012 were randomly divided into three groups： combined treatment group （n= 23, treated with calcipotriol combined with narrow-band ultraviolet） and calcipotriol group （n= 19, only treated with calcipotriol）. The efficacy and adverse reaction were compared between the two groups after 4 weeks of treatment. ResuLts： After 4 weeks of treatment, the effective rate of combined treatment group was much higher than that of calcipotriol group （91.3% vs. 78.9%, P〈0.05）. None severe adverse responses were found in both groups. Conclusion：Calcipotriol combined with narrow-band ultravio- let treatment is safe and effective for palmoplantar pustulosis.

关 键 词：掌跖脓疱病 卡泊三醇 窄谱紫外线 

分 类 号：R730.57[医药卫生—肿瘤]