上海社区抑郁老人认知功能损害的特点  被引量:5

Characteristics of cognitive impairment in depressive elders in Shanghai community

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作  者:程艳[1] 王静华[1] 朱敏捷[1] 王涛[1] 李霞[1] 肖世富[1] 

机构地区:[1]上海交通大学医学院附属精神卫生中心、上海交通大学阿尔茨海默病诊治中心,200030

出  处:《中华医学杂志》2014年第19期1476-1478,共3页National Medical Journal of China

基  金:国家科技支撑计划课题(2009BA177803)

摘  要:目的 探讨上海社区抑郁老人与无抑郁老人认知功能的差异.方法 2011年由上海四个社区中应用SPSS统计软件随机抽样法选取老年人1 068名,由统一培训的心理测评师对所有研究对象进行测评,本研究应用老年抑郁量表(GDS-30)>10分的102例抑郁老人作为抑郁组,并从GDS评分≤10分的无抑郁老人946例中应用SPSS软件随机抽样法选取102例无抑郁老人作为无抑郁组.认知功能评估量表应用蒙特利尔量表(MoCA).结果 抑郁组与无抑郁组比较在MoCA总分(t =2.353)、连线(t=2.236)、注意(t=2.621)、持续注意(t=2.381)、计算(t=2.612)及地点定向(t =2.259)差异有统计学意义(P<0.05).相关结果显示MoCA总分(r=-0.142)、注意(r=-0.161)、持续注意(r=-0.160)、计算(r=-0.150)、流畅性(r=-0.156)、延迟回忆(r=-0.175)及地点定向(r=-0.172)与GDS评分均呈负相关(P<0.05).抑郁组中有认知功能损害者与无抑郁组中有认知功能损害者比较MoCA总分[(14.9±7.3)分比(17.5±6.7)分]、注意[(1.1±0.8)分比(1.4±0.8)分]、计算力[(1.9±1.2)分比(2.3±1.1)分]及地点定向[(1.7±0.7)分比(1.8±0.5)分]差异有统计学意义(P <0.05或P<0.01).结论 抑郁老人认知损害涉及多认知领域,主要表现在注意力、执行功能及地点定向方面.GDS评分与认知功能呈负相关,GDS评分越高,认知功能相对越差.Objective To explore the characteristics of cognitive impairment in depressive elders in Shanghai. Methods A total of 1 068 participants randomly selected from 4 communities in Shanghai underwent neuropsyehiatric and psychiatrists clinical assessment. Among them, 102 depressive ones with a score of geriatric depression scale (GDS) 〉 10 and 102 non-depressive ones with a score of GDS≤10 were selected as depression and non-depression groups respectively. The SPSS statistic software V17.0 was used. Results Significant differences existed between the depressive and non-depressive patients in the total score of Montreal Cognitive Assessment (MoCA) (t =2. 353), trail making B task (t =2. 236) , attention (t = 2. 621 ), sustained attention (t =2. 381 ), calculation (t =2.612) and fixed orientation (t = 2. 259) (P 〈 0.05). The negative correlation had significant inter-group differences in the total score of MoCA (r = -0. 142), attention (r = - 0. 161 ), sustained attention ( r = - 0. 160), calculation ( r = - 0. 150), fluency ( r = - 0. 156) , delayed recall ( r = - 0. 175 ) and orientation to place ( r = - 0. 172) ( P 〈 0.05 ). Cognitive impairment in depression group had lower scores than non-depression group in the total score MoCA ( 14.9 ± 7.3 vs 17.5 ± 6.7), attention ( 1.1 ± 0.8 vs 1.4 ± 0.8), calculation ( 1.9 ± 1.2 vs 2.3 ± 1.1 ) and fixed orientation ( 1.7 ± 0.7 vs 1.8 ± 0.5 ) (P 〈 0.05 ). Conclusion In depressive elders, cognitive impairment occurs in multiple cognitive domains of attention, executive function and orientation to place. There is a negative correlation between GDS score and MoCA. The higher GDS score, the worse cognitive function.

关 键 词:老年抑郁 认知功能损害 神经心理学 

分 类 号:R749.4[医药卫生—神经病学与精神病学]

 

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