NVM-1在肝细胞癌中的表达及临床意义  

Expression of novel metastasis-promoting gene 1 and its clinical significance in hepatocellular carcinoma

作　　者：李嘉璐[1] 黄毓[2] 杨定华[1] 梁博[1] 何华[1] 廖辉[1] 郭柏棠[1] 刘新成[1] 林梁[1] 

机构地区：[1]南方医科大学南方医院肝胆外科,广州510515 [2]南方医科大学南方医院检验科,广州510515

出　　处：《中华医学杂志》2014年第20期1530-1533,共4页National Medical Journal of China

摘　　要：目的 观察NVM-1（Novel metastasis-promoting gene 1）蛋白在肝细胞癌（HCC）中的表达情况及意义.方法 应用免疫组化SP法检测92例HCC癌组织及非癌组织中NVM-1蛋白的表达水平,并分析其与HCC临床病理因素的相关性.结果 NVM-1蛋白主要定位在癌组织的细胞核,NVM-1蛋白在癌组织中阳性表达率（52.2％）高于非癌组织（28.3％）及肝脏良性病变的肝脏组织（0）,差异有统计学意义（P＜0.05）.NVM-1蛋白的表达与肿瘤的TNM分期（P=0.016）、BCLC分期（P=0.015）、病理分化程度（P =0.000）、肝内转移（P =0.002）、门脉癌栓（P=0.023）、复发（P=0.001）显著相关,但与HBV、肿瘤大小、个数、肝硬化等无相关性;Kaplan-Meier分析显示癌组织NVM-1表达阳性组中位无瘤生存时间为5个月,NVM-1表达阴性组中位无瘤生存时间为13个月,两者差异有统计学意义（P=0.001）.结论 HCC癌组织中NVM-1的阳性表达可能与肿瘤的转移复发有密切关系.Objective To explore the expression of NVM-1 （novel metastasis-promoting gene 1） in hepatocellular carcinoma （HCC） tissue and examine its clinical significance.Methods The expression of NVM-1 in 92 cases of HCC tumor tissues and non-tumor tissues was detected by immunohistochemical staining with SP （streptavidin-perosidase）.And its clinical significance was evaluated.Results The staining of NVM-1 was predominantly located in the nucleus of HCC tumor tissue.The positive rate of NVM-1 was 52.2% in all detected cancers and it was higher than that in control non-tumor tissues（28.3%） and benign hepatic lesions （0）.A significant difference of positive rates existed between tumor and nontumor tissues （P 〈 0.05）.The expression of NVM-1 in HCC was not correlated with hepatic B virus （HBV）,size,amount or cirrhosis,etc.However,it was correlated with TNM （P =0.016）,BCLC stage （P =0.015）,poor differentiation （P =0.000）,intrahepatic metastasis （P =0.002）,portal vein tumor thrombus （P =0.023） and recurrence （P =0.001）.By Kaplan-Meier analysis,the median tumor-free survival time was 5 months in positive expression group and it was significantly shorter than 13 months in negative expression group （P =0.001）.Conclusion There is probably a close relation between recurrence and metastasis and the expression of NVM-1 in HCC.

关 键 词：癌 肝细胞 NVM-1 人 复发 肿瘤转移 

分 类 号：R735.7[医药卫生—肿瘤]