骨髓间充质干细胞治疗脊髓损伤的研究进展  

Progress on bone marrow mesenchymal stem cells transplantation for spinal cord injury

作　　者：王郦[1] 王倩[2] 张晓明[2] 

机构地区：[1]浙江医学高等专科学校,浙江杭州310053 [2]浙江大学医学院,浙江杭州310058

出　　处：《中国骨伤》2014年第5期437-440,共4页China Journal of Orthopaedics and Traumatology

基　　金：国家自然基金项目:(No.81272158)~~

摘　　要：骨髓间充质干细胞以其良好的增殖和多向分化能力,取材方便,易于分离培养和自体移植无免疫源性等特征而成为细胞移植治疗脊髓损伤研究的重点之一。目前已证实蛛网膜下腔注射是最理想的骨髓间充质干细胞治疗途径。早期临床应用骨髓间充质干细胞移植是安全的,对脊髓损伤的修复作用是肯定的,其作用机制可能与骨髓间充质干细胞的替代作用、神经营养作用、抑制免疫反应及促进轴突再生等有关。Bone marrow mesenchymal cells （BMSCs） are regarded as donor cells in cell transplantation therapies for spinal cord injury （SCI） for they have the ability of favourable proliferation and multi-directional differentiation, and are easily isolated and culturd and have less immunological reaction. It has been confirmed that subarachnoid space injection is the most ideal delivery technique of BMSCs. Bone marrow mesenchymal stem cells transplantation is safe and its reconditioning role is certain for SCI in early clinical application. The mechanism of BMSCs promoting functional recovery after SCI is probably con- cerned with vicarious function, nerve trophism,immunosuppression and promoting axonal regeneration by BMSCs.

关 键 词：骨髓间充质干细胞 脊髓损伤 干细胞移植 

分 类 号：R542.22[医药卫生—心血管疾病]