hPTTG1与肿瘤发生发展的研究进展  

The research progress of hPTTG1 in the occurrence and development of tumors

作　　者：高英杰[1] 杨娟[1] 张超[1] 韩竞春[1] 

机构地区：[1]大连大学附属新华医院肿瘤科,辽宁大连116021

出　　处：《临床肿瘤学杂志》2014年第5期469-472,共4页Chinese Clinical Oncology

摘　　要：人垂体瘤转化基因(hPTTG)是一种潜在的癌基因,自发现以来一直是研究的热点,在人体肿瘤中主要表达hPTTG1,且在多种肿瘤中高表达。研究证实,hPTTG1具有促进细胞转化、血管生成及肿瘤转移等生物学功能,在肿瘤的发生、发展、侵袭、转移及复发中起重要作用。hPTTG1对肿瘤的诊断具有重要的参考价值,有望成为肿瘤基因治疗的新靶点。As a potential oncogene, human pituitary tumor transforming gene（ hPTTG） has been always the research foucs since it was discovered. hPTTG1 is mainly expressed in human tumors and highly expressed in a variety of tumors. Related studies have shown that hPTTG1 has the function of promoting cell transformation, angiogenesis, tumor metastasis and other biological functions. Be-sides, it plays an important role in tumorigenesis,occurrence,development,invasion, metastasis and recurrence of tumors. hPTTG1 has important reference value for diagnosis of tumor, and it represents potential target for gene therapy of tumor.

关 键 词：人垂体瘤转化基因1( hPTTG1) 肿瘤 

分 类 号：R730[医药卫生—肿瘤]