CD133及CD44在非小细胞肺癌中的表达及意义  

CD133 and CD44 expression in non- small- cell lung cancer( NSCLC) and its clinical significance

作　　者：宋仕茂[1] 何晓文 

机构地区：[1]湖北医药学院附属太和医院肿瘤科,湖北十堰442000 [2]湖北省人民医院放疗科,湖北武汉430060

出　　处：《现代肿瘤医学》2014年第6期1318-1320,共3页Journal of Modern Oncology

基　　金：湖北科技攻关计划资助项目(编号:2006AA402C51)

摘　　要：目的:研究CD133及CD44在非小细胞肺癌组织中的表达及意义。方法:免疫组织化学方法检测非小细胞肺癌组织和癌周组织CD133及CD44的表达,并分析其表达与肺癌临床病理特征的关系。结果:CD133和CD44在非小细胞肺癌组织中均见表达。CD133及CD44的表达与是否有淋巴结转移有关(P<0.05),与细胞分化程度、临床TNM分期无显著相关。结论:CD133及CD44与非小细胞肺癌发展密切,对非小细胞肺癌早期诊断和靶向治疗具有重要意义。Objective：To study CD133 and CD44 expression in non-small-cell lung cancer（ NSCLC）and its clinical significance. Methods：Immunohistochemical staining was performed to detect expression of CD133 and CD44 in NSCLC and cancerous peripheral tissue,and analyze the relationship between their expression and clinicopathologic characteristics. Results：CD133 and CD44 expression in NSCLC was determined. Expression level of CD133 and CD44 was significantly related to lymph node metastasis（P〈0. 05）and not significantly related to cell differentiation and TNM stage. Conclusion：CD133 and CD44 had a close relationship with NSCLC development and had important role for early diagnosis and targeted therapy of NSCLC.

关 键 词：非小细胞肺癌 CD133 CD44 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]