EZH2在前列腺癌中的表达及临床意义  

The expression of EZH2 in the prostate cancer tissues and its clinical significance

作　　者：苏燕胜[1] 李富军[1] 高云[1] 贾红兵[1] 王倩云[1] 秦卫军[2] 温伟红[3] 王禾[4] 

机构地区：[1]解放军第323医院泌尿外科,陕西西安710054 [2]第四军医大学西京医院泌尿外科,陕西西安710032 [3]第四军医大学免疫教研室,陕西西安710032 [4]第四军医大学唐都医院泌尿外科,陕西西安710032

出　　处：《现代肿瘤医学》2014年第6期1351-1353,共3页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:30973000)

摘　　要：目的:研究EZH2在前列腺癌中的表达及临床意义。方法:利用免疫组化的方法研究EZH2在前列腺良性增生性病变组织与前列腺癌组织中的表达,分析EZH2的表达与肿瘤Gleason评分之间的关系。结果:EZH2在前列腺癌细胞中高表达,其高表达趋势与前列腺癌的Gleason评分水平成正相关。结论:EZH2蛋白的异常表达可能在前列腺癌的生长、浸润和转移过程中起促进作用,可能成为一种反映前列腺癌生物侵袭性的标志物。Objective：To determine the expression of EZH2 in the prostate cancer tissues and to estimate its clini-cal significance. Methods：Immunohistochemistry was performed to detect EZH2 expression in malignant tumor of prostate and the tissue of benign neoplasia was used as the control. Results：EZH2 expressed with a much higher level in prostate cancer tissues with comparison to that in the benign neoplasia. And its expression trend was correlated with the malignant degree of the carcinoma. Conclusion：The abnormal expression of EZH2 could play a very important role in promoting the proliferation,invasion and metastasis of the prostate cancer,and the EZH2 could be a marker to re-flect the invasion ability of prostate cancer.

关 键 词：前列腺癌 免疫组织化学法 EZH2 

分 类 号：R737.25[医药卫生—肿瘤]