TACE与γ刀治疗原发性肝癌时序探讨  

Effect of timing of transcatheter arterial chemoembolization with gamma ray stereotactic radiotherapy for primary liver cancer

作　　者：柯传庆[1] 彭恩兰[1] 彭秋平[1] 熊勰[1] 

机构地区：[1]解放军第94医院肿瘤科,江西南昌330002

出　　处：《现代肿瘤医学》2014年第6期1372-1374,共3页Journal of Modern Oncology

摘　　要：目的:探讨经肝动脉插管化疗栓塞术(TACE)和γ射线立体定向放射(γ刀)在不同时序上介入对原发性肝癌的疗效。方法:将53例原发性肝癌患者分为A、B两组,A组先行TACE后行γ刀治疗,B组先行γ刀后行TACE治疗,对照分析两组在疗效、生存期、复发时间、不良反应等方面的差异。结果:两组有效率分别为77.4%和77.3%,随访6、12、18个月,生存率分别为96.8%、80.6%、77.4%和63.6%、45.5%、18.2%。复发率分别为0%、16.1%、35.5%和18.2%、40.9%、77.3%。不良反应相似。结论:两组在有效率方面无差异,但在生存期和复发时间方面A组明显优于B组,而不良反应相似,表明不同方法在不同时序上介入对原发性肝癌治疗结果有直接影响。Objective：To investigate the difference in the efficacy of transcatheter arterial chemoembolization（ TA-CE）and gamma ray stereotactic radiotherapy（γknives）in different timing for primary liver cancer. Methods：All 53 patients with primary liver cancer were divided into two groups,patients in group A was treated with TACE and then with gamma knife,patients in group B was treated with gamma knife and then with TACE. To compare the efficacy, survival,recurrence time,adverse reaction between the two groups. Results：The efficacy were 77. 4% and 77. 3% in two groups,and after 6,12,and 18 months of follow-up,survival rates were 96. 8%,80. 6%,77. 4% and 63. 6%, 45. 5%,18. 2%,and recurrence rates were 0%,16. 1%,35. 5% and 18. 2%,40. 9%,77. 3%,and had similar ad-verse reactions. Conclusion：The treatment in two groups had no significant difference in efficacy,but the survival and recurrence time in group A was significantly better than group B,and had similar adverse reactions,indicated that the different timing of interventional treatment for primary liver cancer had directly impact on treatment outcomes.

关 键 词：原发性肝癌 经肝动脉插管化疗栓塞术 γ射线立体定向放射 时序 

分 类 号：R735.7[医药卫生—肿瘤]