血管生成与胆囊癌发展和预后的关系  

RELATIONSHIP OF ANGIOGENESIS WITH PROGRESSION AND PROGNOSIS OF GALLBLADDER CARCINOMA

作　　者：白涛[1] 郭仁宣[1] 王浩[2] 

机构地区：[1]中国医科大学附属第一院普外科,沈阳110001 [2]沈阳华泰医院外科,沈阳110031

出　　处：《中国普外基础与临床杂志》2001年第2期101-103,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　探讨肿瘤微血管密度 (MVD)与胆囊癌的侵袭转移和预后的关系。方法　应用免疫组化法 ,用抗人因子Ⅷ相关抗原 (FⅧRAg)的单克隆抗体测定 42例人胆囊癌组织中的MVD ,并分析其与胆囊癌各种病理因素及预后之间的关系。结果　MVD与胆囊癌浸润深度 (P <0 0 5 )、淋巴结转移 (P <0 0 1)和远处转移 (P <0 0 5 )密切相关 ,而与病理类型、分化程度无关 (P >0 0 5 ) ;MVD >5 4 82的胆囊癌患者 5年生存率较低。结论　肿瘤微血管密度与胆囊癌浸润深度、淋巴结及远处转移密切相关 ,对判断胆囊癌的预后具有重要的临床意义。Objective\ To investigate the relationship between microvessel density(MVD) and lymph node metastasis and prognosis in gallbladder carcinoma. Methods\ The MVD in 42 gallbladder carcinoma by immunohistochemical SP method using a polyclonal antibody to FⅧ and the relationship between MVD and histologic types, depth of invasion, lymph node metastasis, distant metastasis and prognosis was studied. Results\ The value of MVD was correlated with the depth of invasion (P<0.05), lymph node metastasis (P<0.01) and distant metastasis (P<0.05). It was not significantly related to the pathologic pattern and tumor differentiation. The significantly negtive correlation was found between MVD and 5-year survival in patients with gallbladder carcinoma. Conclusion\ MVD is strongly related to the metastasis of gallbladder carcinoma. It may serve as a prognotic factor.

关 键 词：胆囊肿瘤 血管生成 微血管密度 预后 MVD 

分 类 号：R735.8[医药卫生—肿瘤]