肿瘤耐药相关鞘糖脂CMH对人树突状细胞B7表达的影响  

INFLUENCE OF TUMOR MDR ASSOCIATED CMH ON THE EXPRESSION OF B7 IN DC

作　　者：张健[1] 张积仁[1] 汪森明[1] 赵燕[1] 王兵[1] 

机构地区：[1]第一军医大学珠江医院,广州510282

出　　处：《解放军医学杂志》2001年第3期169-170,F003,共3页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金资助课题! (编号 3 9870 83 1);广东省自然基金资助课题!(编号 0 0 10 41)

摘　　要：为了探讨肿瘤耐药相关鞘糖脂CMH在耐药肿瘤细胞免疫逃避中的作用 ,用柱层析的方法分离纯化了KBv2 0 0 细胞的耐药相关中性鞘糖脂CMH ,采用流式细胞仪技术检测CMH作用前后人树突状细胞 (DC)B7抗原的表达。结果显示 ,CMH明显地抑制DCB7抗原的表达 。To investigate the role of tumor multidrug resistance (MDR) associated with CMH in the immunological evasion of MDR tumor cells, CMH was separated from neutral glycolipids of KBv 200by column chromatography, and the expression of B7 in DC was detected by flow cytometry. The results showed that the expression of B7 in DC was inhibited by CMH, it suggested the tumor MDR associated with glycolipids may inhibit human immune response by its effects on DC.

关 键 词：多药抗药性 中性糖苷神经鞘脂类 树突细胞 CMH 免疫逃避 肿瘤 

分 类 号：R73－34[医药卫生—肿瘤] R73－361[医药卫生—临床医学]