低温保存血小板临床应用效应研究  

EFFECT OF CRYOPRESERVED PLATELETS TRANSFUSION ON 1560 PATIENTS

作　　者：刘景汉[1] 王青梅[1] 李锡金[1] 石群[1] 骆群[1] 韩玮[1] 欧阳锡林[1] 高大勇 

机构地区：[1]解放军总医院,100853 [2]University of Kentuky Lexington

出　　处：《解放军医学杂志》2001年第3期222-223,共2页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金资助课题! (编号 89970 812 )

摘　　要：对 15 6 0例输注低温保存血小板的临床患者进行了研究。其中急性白血病 5 36例 ;再生障碍性贫血2 85例 ;化疗和放疗及其他原因所致的血小板减少 2 5 3例 ;围手术期患者 438例 ;DIC、肝硬化食管静脉曲张破裂出血 48例。输注的低温保存血小板保存时间为 1周～ 8个月居多 ,保存时间最长 13个月。输注的血小板基本上未经洗涤。结果显示 ,输注低温保存的血小板具有升高血小板作用和显著的止血效果 ,且无明显副作用。低温保存血小板在临床应用中 ,从数量保证、供给形式和及时有效等方面都是其他方法获得的血小板所不能比拟的。In this study, cryopreservated platelets were transfused to 1560 patients. of them, 536 were patients with acute leukaemia, 285 with anemia, 253 with thrombocytopenia due to chemical or radicalized treat, 438 in perioperation, and 48 with DIC or hemorrhage of rupture esophagus varix. The storage time of cryopreserved platelets ranged from one week to thirteen months. Most of the cryopreserved platelets had not been washed before application and no obvious adverse-effects were observed except for garlic smell in patients' exhalation after transfusing cryopreserved platelets. The results showed that transfusion of cryopreserved platelets has a remarkable on effect hemostasis and can enhance the platelet count in peripheral blood. Compared with liquid-preserved platelets, cryopreserved platelets for clinic use have the following advantages:1) the potentiality of large stock, 2) much longer shelf life, 3) higher safety, 4) superior hemostasis effect, and 5) capacity to meet emergent massive clinic demand.

关 键 词：血液保存 成份输血 低温保藏 

分 类 号：R457.1[医药卫生—治疗学] R318.52[医药卫生—临床医学]