180例垂体腺瘤的临床病理观察  

Pituitary adenoma:A clinicopathologic analysis of 180 cases

作　　者：牛俊扬[1] 宋怡诚[2] 周荣妹[1] 王晓秋[1] 胡闻[1] 程荣璇[1] 

机构地区：[1]安徽省立医院病理科,合肥230001 [2]合肥市第一人民医院脑外科,合肥230061

出　　处：《临床与实验病理学杂志》2001年第1期42-44,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的 :研究垂体腺瘤的临床激素过多症状与腺瘤组织激素检测之间的关系以及该病的发生、生物学行为、分类。方法 :对 180例垂体腺瘤进行了临床病理分析 ,并对其中 110例应用免疫组化ABC法检测了肿瘤的GH、PRL、ACTH、TSH、FSH、LH。结果 :临床激素过多症状与激素检测相一致者占 40 % ,且女性较男性相一致者多 ,差异有显著性。免疫组化分型以PRL和GH腺瘤多见 ,多激素腺瘤以GH +PRL腺瘤多见。结论 :垂体腺瘤的免疫组化检测与形态功能相结合的分类方法简便易行较为实用。Purpose To study the histogenesis,biological behaviour,classification of pituitary adenoma and the relationship between the symptoms of hormonal hypersecretion and the hormone test in pituitary adenoma. Methods One hundred and eighty cases of pituitary adenoma were investigated by clinicopatholgic analysis, and GH,PRL,ACTH,TSH,FSH,LH were examined in 110 cases by ABC immunocytochemical methods. Results Forty percent of the patients were found to have the identical results between the clinical symptoms and hormonal test. Female patients were more than male ones,and the difference was satistically significant. The results showed that PRL and GH adenoma were often found in the cases by immunocytochemical method,and mixed GH PRL adenoma were often found in the cases with multihormono adenoma. Conclusion The classification is practical and easy to operate,which combines the immunohistochemical examination of pituipary adenoma with the morphology and function.

关 键 词：垂体腺瘤 临床病理 激素 检测 

分 类 号：R736.4[医药卫生—肿瘤]