改进的QuEChERS气相色谱-质谱法检测豆浆中18种邻苯二甲酸酯  

Determination of 18 Phthalate Acid Esters in Soya Bean Milk Using the Modified QuEChERS Sample Preparation Method and Gas Chromatography-Mass Spectrometry

作　　者：荣维广[1] 阮华[1,2] 马永建[1] 吉文亮[1] 刘华良[1] 吴建[1] 宋宁慧[3] 

机构地区：[1]江苏省疾病预防控制中心,江苏南京210009 [2]东南大学公共卫生学院,江苏南京210009 [3]环境保护部南京环境科学研究所,江苏南京210042

出　　处：《分析科学学报》2014年第3期332-336,共5页Journal of Analytical Science

基　　金：国家自然科学基金(No.41101307);江苏省科技厅科技支撑计划(No.BE2010745);江苏省疾病预防控制中心"科教兴业工程"项目(No.JKRC2011030)

摘　　要：建立了豆浆中18种邻苯二甲酸酯类增塑剂的QuEChERS提取净化，气相色谱一质谱法检测技术，内标法定量。考察了基质效应，QuEChERS萃取技术。样品用乙腈均质提取，采用PSA、LC—C18和Envi-carb混合填料分散萃取净化。在优化的条件下，18种增塑剂均具有较好的线性相关性，线性相关系数均大于0．9976，添加回收率、相对标准偏差分别为84．6％～101．1％、2．1％～5．800；方法的检出限均小于0．05mg／kg。该方法操作简单，快速，环保，灵敏度高，准确度好。This work reports a rapid, specific and sensitive multi-residue method based on the Quick Easy Cheap Effective Rugged and Safe（QuEChERS） sample preparation method and gas chromatography with mass spectrometry detection in the selected ion monitoring mode（GC-MS SIM） using isotope internal standard for the routine analysis of 18 phthalate acid esters（PAEs） in Soya bean milk. Matrix effect and QuEChERS methods was carefully investigated. Soya bean milk was extracted by acetonitrile, then cleaned-up using solid phase extraction with mixed sorbents of anhydrous magnesium sulfate,PSA, LC- C18 and Envi-carb. 18 PAEs showed good linearity with all R2 higher than 0. 9976. The recovery and relative standard devition（RSD） were 84.6 %- 101.1% and 2.1% 5.8 %, respectively. The method was sensitive with the detection limits lower than 0.05 proved to be convenient, time -saving, environmental mg/kg （S/N=3）. The developed method has been -friendly,accurate and sensitive.

关 键 词：豆浆 增塑剂 邻苯二甲酸酯 气相色谱一质谱法 QUECHERS 

分 类 号：O657.63[理学—分析化学]