53例涎腺腺样囊性癌MMP-2和MMP-9表达与神经浸润和淋巴结转移的关系  

Expression of MMP-2 and MMP-9 in 53 Cases of Salivary Adenoid Cystic Carcinoma and Its Relationship with Invasion and Metastasis

作　　者：唐峰[1] 王虹[1] 赵为之[1] 李薇[1] 李琼[1] 庄丽[1] 

机构地区：[1]复旦大学附属华山医院外科病理室,上海200040

出　　处：《复旦学报（医学版）》2001年第2期121-123,F003,共4页Fudan University Journal of Medical Sciences

摘　　要：目的　研究涎腺腺样囊性癌MMP 2和MMP 9表达情况 ,评估其与涎腺腺样囊性癌神经浸润和淋巴结转移的关系。方法　选取 5 3例涎腺腺样囊性癌 ,以抗MMP 2和MMP 9单克隆抗体用Envision法进行免疫组织化学染色和半定量分析。结果　MMP 2和MMP 9在涎腺腺样囊性癌中的表达率分别为 6 7.92 %和79.2 5 % ;有神经浸润的腺样囊性癌其MMP 2和MMP 9的表达水平远高于无浸润者 (P <0 .0 5 ,P <0 .0 5 ) ;随着MMP 2和MMP 9的表达水平增高 ,淋巴结转移率也增高 (P <0 .0 5 ,P <0 .0 5 )。结论　提示MMP 2和MMPPurpose: To study the patterns of the expression of MMP-2 and MMP-9 in human salivary adenoid cystic carcinoma and evaluate the relationship between the expression and nerve invasion and lymph node metastasis. Methods: The immunohistochemical location of MMP-2 and MMP-9 was evaluated by using Envision immunoperoxidase technique. Studies were performed in 53 surgical excised specimens. The immunohistochemical staining results were densitometrically semiquantitatived. Results: The expressions of MMP-2 and MMP-9 in salivary adenoid cystic carcinoma were 67.92% and 79.25% respectively. The MMP-2 and MMP-9 levels in salivary adenoid cystic carcinoma with nerve invasion were much higher than those without invasion(P<0.05, P<0.05 respectively), and the percentage of lymph node metastasis rose with the change of MMP-2 and MMP-9 (P<0.05, P<0.05 respectively). Conclusions: The results indicate that the rise of MMP-2 and MMP-9 correlate with the nerve invasion and lymph node metastasis.

关 键 词：金属蛋白酶 涎腺腺样囊性癌 肿瘤浸润 肿瘤转移 淋巴结转移 MMP-2 神经浸润 MMP-9 

分 类 号：R739.87[医药卫生—肿瘤] R73－37[医药卫生—临床医学]