氨磷汀的合成  

Synthesis of Amifostine

作　　者：毛远湖[1] 汤磊[1] 王建塔[1] 

机构地区：[1]贵阳医学院,贵州贵阳550004

出　　处：《广州化工》2014年第11期64-65,共2页GuangZhou Chemical Industry

基　　金：贵阳医学院基金合同字第(2009)32号资助

摘　　要：以2-羟基乙胺为原料,与丙烯腈反应后经还原、溴代、成盐、精制得细胞保护剂氨磷汀,中间体及终产物结构经红外、氢谱确证,并通过HPLC与终产物标准品对照测得其纯度。新的工艺对各步反应进行了优化,收率达37.3%,纯度达99.2%。Amifostine , a cytoprotector , was synthesized by reaction of 2 -Aminoethanol with acrylonitrile and via condensation, bromination, salification, and purified.The structures of the intermediates and final product were characterized by IR and 1^ HNMR, and the purity was measured via HPLC by contrast with standard substance.By optimizing each step , the total yield was raised to 37.3%and purity of 99.2%.

关 键 词：氨磷汀 细胞保护剂 合成 

分 类 号：R914.5[医药卫生—药物化学]