儿童肝母细胞瘤25例临床分析  

Clinical analysis of childhood hepatoblastoma

作　　者：侯维纳[1] 邹湘[1] 郭佳[1] 王璐[1] 盛光耀[1] 孙素珂 

机构地区：[1]郑州大学第一附属医院儿科,河南郑州450052 [2]河南省高等学校临床医学重点开放实验室,河南郑州450052

出　　处：《临床儿科杂志》2014年第5期417-420,共4页Journal of Clinical Pediatrics

摘　　要：目的：总结儿童肝母细胞瘤（HB）的治疗效果，探讨合理治疗策略。方法回顾性分析2009年2月至2013年3月初治的HB患儿的临床及随访资料。结果入选25例初治HB患儿，男14例、女11例，中位发病年龄为25个月（3-92个月）。其中原发肿瘤完整切除18例，存活17例；未完全切除7例，仅1例存活；原发肿瘤完整切除者的生存率明显高于未完整切除者，Ⅰ、Ⅱ期患儿生存率明显高于Ⅲ、Ⅳ期患儿，差异均有统计学意义（P均〈0.05）。结论手术完整切除是所有临床分期的HB患儿获得长期无瘤生存的关键，对于复发和转移的HB患儿的治疗策略有待进一步完善。Objectives To investigate the rational treatment strategy of hepatoblastoma （HB） in children. Methods Clinical data and follow-up of 25 children with HB admitted from February 2009 to March 2013 were retrospectively analyzed. Results Twenty-five children with newly diagnosed HB （14 males and 11 females） were enrolled. The median age on diagnosis was 25 months （3-92 months）;In 18 of 25 cases with complete resection of the primary tumor, 17 cases survived. Only 1 of 7 cases with incomplete resection survived. The survival rate in children with complete resection of primary tumor is significantly higher than those without complete resection （P〈0.05）. The survival rate in children of stage Ⅰ or Ⅱ is significantly higher than the children of stage Ⅲ or Ⅳ （P〈0.05）. Conclusions Complete tumor resection is the cornerstone of therapy for long-term disease-free survival in HB patients. Treatment strategy remains to be further improved for children with recurrent and metastatic HB.

关 键 词：肝母细胞瘤 治疗 儿童 

分 类 号：R735.7[医药卫生—肿瘤]