抗病毒治疗对HBVDNA阳性肝癌患者术后临床转归的影响  被引量:3

Impact of antiviral therapy on postoperative clinical outcomes of HBV DNA positive hepatocellular carcinoma patients

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作  者:陈一杰 何谦 张诚华 刘琦 刘朝辉 

机构地区:[1]解放军第一八○医院胃肠及肝胆外科,福建泉州362000

出  处:《肝脏》2014年第4期238-240,共3页Chinese Hepatology

摘  要:目的:探讨抗病毒治疗对 HBV DNA阳性肝癌患者术后临床转归的影响。方法2008年至2013年我院共收治50例接受肝癌根治切除手术治疗的HBV DNA阳性肝癌患者,将这些患者分为观察组和对照组,每组25例。对照组患者单纯手术治疗,观察组患者手术切除联合拉米夫定抗病毒治疗。结果术后6个月观察组患者的AST、ALT、TBil水平均较对照组显著降低,Alb 水平较对照组增高(P<0.05);术后3个月和6个月观察组患者的 HBV DNA、Child-Pugh评分均较对照组显著降低(P<0.05);观察组患者的存活中位数明显较对照组大,1~2年、2~3年、3年以上无瘤生存率均较对照组显著升高(P<0.05)。结论抗病毒治疗能够有效改善手术治疗的 HBV DNA阳性肝癌患者的预后。Objective To investigate the impact of antiviral therapy on the prognosis of HBV-DNA positive hepatocellular carcinoma patients after surgical treatment. Methods Fifty HBV-DNA positive hepatocellular carcinoma patients after curative resection in our hospital from 2008 to 2013 were enrolled,which were divided into observation group and control group (25 cases in each group).The patients in control group were given surgery alone,while the patients in observation group were given surgical resection in combination with lamivudine antiviral therapy. ResultsCompared to control group,the AST,ALT and TBil levels of observation group in 6 months were significantly lower, while the Alb level was significantly higher(t= 2.571,P〈0.05);The HBV DNA,Child-Pugh scores in 3 months and 6 months were significantly lower(t= 2.365,P〈0.05);There was obviously higher median survival rate of disease-free survival rates for 1-2 years,2-3 years and more than 3 years in observation group,(χ2 = 0.024,P〈0.05).Conclusions Antiviral therapy can improve the prognosis of HBV-DNA positive hepatocellular carcinoma patients after surgical treatment.

关 键 词:抗病毒治疗 HBV DNA 肝癌 

分 类 号:R735.7[医药卫生—肿瘤]

 

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