髓样抑制细胞在结肠癌耐药发生中影响机制的研究进展  

Research Progress in Influencing Mechanism of Myeloid Suppressor Cells on Drug Resistance of Colon Cance

作　　者：王小红[1] 

机构地区：[1]浙江省肿瘤医院肿瘤内科,杭州310022

出　　处：《抗感染药学》2014年第2期103-105,共3页Anti-infection Pharmacy

基　　金：浙江省卫生厅研究资助课题项目A类(编号:2013KYA023)

摘　　要：结肠癌在临床较为常见，占消化道肿瘤的 5%-8%，老年人较为多发，随着我国社会生活水平的逐步提高和生活节奏的加快，老年结肠癌发病率也呈现上升趋势，而结肠癌的耐药性往往严重影响治疗的效果，使得效果不尽如人意。髓样抑制细胞（MDSC）是一群来源于骨髓的幼稚细胞，具有很强的免疫抑制作用，是引起肿瘤免疫逃逸的重要细胞群。综述髓样抑制细胞在结肠癌耐药发生中影响机制的研究进展文献，并对其作了分析与展望。Colon cancer is very common especially in elderly people, and it accounts for 5%-8% of gastrointestinal tumors. With the development of our social life level and acceleration of life rhythem, senile colon cancer morbili-ty also is rising. Currently, the main treatment method for advanced stage of colon cancer is chemotherapy, but drug resistance makes its theraputic effect unsatisfactory. Myeloid suppressor cells （MDSC） are a flock of heterogeneous cells, including inmmature macrophages, dendritic ceils and granulocytes which possess strong immunosuppressive actions and are the important cell group that causes tumor immune escape. This article elaborates the research progress of influencing mechanism of myeloid suppressor cells on drug resistance of colon cancer.

关 键 词：髓样抑制细胞 结肠癌 耐药 

分 类 号：R914[医药卫生—药物化学]