羟喜树碱联合顺铂热灌注治疗晚期肝癌腹腔积液  

Intraperitoneal hyperthermal chemotherapy with HCPT and cisplatin in treatment of advanced hepatic cell carcinoma with malignant ascites

作　　者：秦志楠[1] 夏兴洲[1] 张自森[2] 吴茜[1] 王世超[1] 

机构地区：[1]郑州大学第五附属医院消化内科,郑州450052 [2]郑州大学第五附属医院肿瘤科

出　　处：《医药论坛杂志》2014年第5期20-21,24,共3页Journal of Medical Forum

基　　金：郑州市科技发展计划项目(2010SFXM345)

摘　　要：目的探讨羟喜树碱(HCPT)联合顺铂热化疗对人肝癌细胞的毒性增效作用,观察其腹腔热灌注治疗肝癌癌腹腔积液的疗效。方法流式细胞术检测温热条件下HCPT联合顺铂处理后肝癌细胞的凋亡。观察48例晚期肝癌腹腔积液患者热灌注化疗的疗效及不良反应。检测治疗前后血清AFP水平变化。结果 HCPT联合顺铂化疗显著增加对肝癌细胞的细胞凋亡率。热灌注HCPT联合顺铂治疗肝癌腹腔积液的有效率为60%(18/30),显著高于顺铂单药灌注组38.9%,不良反应轻微。血清AFP治疗后显著下降,且与疗效相关。结论 HCPT联合顺铂热化疗能显著诱导肝癌细胞凋亡,热灌注HCPT联合顺铂是晚期肝癌腹腔积液安全有效的治疗方法。Objective To investigate whether hyperthermia combined with HCPT and eisplatin enhances drug sensitivity in hepatic cancer cell, and to evaluate the efficacy of intraperitoneal hyperthermal chemotherapy with them in the treatment of malinant ascites. Methods The apoptosis rate were measured by flow cytometry in H22 hepatic cancer cells treated with HCPT and cisplatin. Forty - eight cases of advanced ovarian carcinoma with malignant ascites were treated with intraperitoneal hyperthermal with HCPT and cisplatin, and the ascites control rate and the main side effects were observed. Results Hyperthermia at 42℃ for 60min combined with HCPT and cisplatin increased apoptosis rate of H22 cells significantly. The ascites control rate was 60% （18/30） in the set of HCPT and cisplatin, significantly higher than that in the set of cisplatin, whiIe the toxicity and the side effects were toierabie. Conclusion Hyperthermia combined with HCPT and cisplatin could induce more apoptosis in H22 cancer cell, and intraperitoneal hyperthermal with them is more efficient and safety in the treatment for maIignant ascites in patients with advanced hepatic carcinoma.

关 键 词：热疗 化疗 肝癌 恶性腹腔积液 

分 类 号：R735.2[医药卫生—肿瘤]