奥拉西坦治疗慢性精神分裂症认知功能障碍的疗效  

The Effect of Oxiracetem on the Cognitive Function of Chronic Schizophrenics

作　　者：严冬梅[1] 郭伟[1] 张新风[1] 周丽芳[1] 樊园媛 韩刚亚[1] 

机构地区：[1]中国.湖北省荆州市精神卫生中心,434000

出　　处：《中国健康心理学杂志》2014年第5期649-650,共2页China Journal of Health Psychology

摘　　要：目的探讨奥拉西坦对慢性精神分裂症认知功能的影响。方法将78例慢性精神分裂症患者随机分成研究组和对照组各39例,所有患者均服用利培酮2~6mg/d,研究组合用奥拉西坦胶囊2400mg/d,对照组合用安慰剂（奥拉西坦模拟胶囊）。疗程为16周。治疗前与治疗16周末采用阳性与阴性症状量表（PANSS）评定临床疗效,威斯康辛卡片分类测试（WCST）评定认知功能,同时观察不良反应。结果研究组脱落2例,对照组脱落3例。治疗16周末,两组临床疗效差异无统计学意义。研究组患者认知功能测试在正确次数、持续错误数、随机错误数和完成分类数4项指标上较治疗前显著改善,有统计学意义（P均〈0.05）,而对照组各项指标均无明显改善,无统计学意义。安全性方面,研究组和对照组不良反应总发生率分别为48.6%（18/37）和41.7%（15/36）,两组间差异无统计学意义,且不良反应均较轻微。结论利培酮联合奥拉西坦治疗对慢性精神分裂症患者的认知功能障碍有较好的改善作用,不良反应轻。Objective To explore the effect of oxiracetem on the cognitive function of chronic schizophrenics .Methods A total of 78 chronic schizophrenics were randomly divided into two groups （each n=39）：Research group took risperidone （2~6mg/d）plus ox-iracetem（2400mg/d）and control group took risperidone plus placebo （oxiracetem mock capsule）for 16 weeks.Assessments were conduc-ted with the Positive and Negative Syndrome Scale （PANSS）,Wisconsin Card Sorting Test（WCST）before and after the treatment.Results After 16 weeks of treatment , the two groups had no statistically significant difference in clinical efficacy .Cognitive improvement was significant in the research group in the corrects ,preservatives errors ,random errors ,categories completes of WCST after treatment .There was no significant improvement in all the measurement index in the control group .The total incidence of adverse reactions were 48.6%（18/37）in the research group and 41.7%（15/36）in the control group respectively .There were no significant difference between the two groups in the total incidence of adverse reactions , and the adverse reactions were mild .Conclusion Risperidone combined with ox-iracetem can improve the cognitive function of chronic schizophrenics with few adverse effects .

关 键 词：奥拉西坦 利培酮 慢性精神分裂症 认知功能 

分 类 号：B845.4[哲学宗教—心理学] R749.3[医药卫生—神经病学与精神病学]