丙戊酸钠对癫痫患儿体重的影响及作用机制  

Effect of Valproic Acid Treatment on the Body Weight of Pediatric Patients with Epilepsy and Its Mechanism

作　　者：何晓英[1] 付华[2] 刘永刚[1] 李小刚[1] 

机构地区：[1]泸州医学院附属医院神经内科,四川泸州646000 [2]泸州医学院附属医院乳腺外科,四川泸州646000

出　　处：《中外医疗》2014年第11期8-9,共2页China & Foreign Medical Treatment

摘　　要：目的研究丙戊酸钠(VPA)对癫痫患儿体重的影响及其机制。方法按照纳入标准收集泸州医学院附属医院神经内科门诊2011年5月—2013年5月首次诊断癫痫后VPA单药治疗的患儿48例作为实验组,于治疗前、治疗后1、3、6个月检测患儿体质量指数(BMI)及血清瘦素水平。另选择健康儿童24例作为对照组。结果实验组治疗后1、3、6个月BMI及血清瘦素均呈现出上升趋势,且两者在各时间点均明显高于对照组,差异有统计学意义(P<0.05)。结论 VPA可增加癫痫患儿体重,其机制可能与显著上调血清瘦素水平有关。Objective To study the effect of valproic acid （VPA） on the body weight of pediatric patients with epilepsy and its mechanism. Methods 48 pediatric patients first diagnosed with epilepsy in Neurology Clinic of The Affiliated Hospital of Luzhou Medical College and treated with VPA from May, 2011 to May, 2013 were selected as the experimental group according to the in-clusion criteria. The parameters of body mass index （BMI） and the serum content of leptin of them were detected before treatment and at 1, 3, 6 months after treatment. And 24 healthy children were selected as the control group. Results The BMI and the serum leptin of the experimental group both showed uptrend at 1, 3, 6 months after treatment, which were significantly higher than those of the control group at the same time point, the differences were statistically significant （ P〈0.05）. Conclusion VPA can significant-ly increase the body weight of pediatric patients with epilepsy, and it may be related to the up-regulation of the serum leptin level.

关 键 词：丙戊酸钠 癫痫 瘦素 

分 类 号：R742.1[医药卫生—神经病学与精神病学]