Multiresponsive Polymer Assemblies Achieved by a Subtle Chain Terminal Modification  

作　　者：Weiwei Liu Yucai Wang Yang Li Feng Wang Xianzhu Yang Tianmeng Sun Jinzhi Du Jun Wang 

机构地区：[1]Nano Science and Technology Institute, University of Science and Technology of China, Suzhou, Jiangsu 215123, China [2]Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China [3]CAS Key Laboratory of Brain Function and Disease and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China [4]School of Medical Engineering, Hefei University of Technology, Hefei, Anhui 230009, China Email: Xianzhu Yang ([e-mail]), Jun Wang ([e-mail])[*]CAS Key Laboratory of Brain Function and Disease and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China, Tel.: [phone] Fax: [phone]

出　　处：《Chinese Journal of Chemistry》2014年第1期51-56,共6页中国化学（英文版）

基　　金：This work was supported by the Ministry of Science and Technology of China (Nos.2010CB934001,2012AA022501,2013CB933900),the National Natural Science Foundation of China (Nos.51203145,51125012),the Fundamental Research Funds for the Central Universities (No.WK2070000008) and the Open Project of State Key Laboratory of Supramolecular Structure and Materials (No.SKLSSM201301).

摘　　要：Inspired by the influence of chemical structure of end groups on the phase transition temperature of thermoresponsive polymers,we demonstrated a strategy to control the multi-responsiveness of polymer assemblies via subtle modification of end groups of thermoresponsive polymer segments and revealed its potential application for drug delivery.By developing polymer assemblies composed of poly(aliphatic ester) as the inner core and thermoresponsive polyphosphoester as the outer shell,we showed that end groups of thermoresponsive polyphosphoester segments controlled the surface property of assemblies and further determined the stimuli-responsive behavior.The phase-transition temperatures of the unmodified polymer assemblies are tightly controlled by their surface properties due to the hydrophilic to hydrophobic transitions of end groups in response to an environmental stimulus (e.g.pH or light irradiation).External control over these surface properties can by asserted by adjusting the chemical structure and composition of the terminal groups of the thermoresponsive polyphosphoesters.Inspired by the influence of chemical structure of end groups on the phase transition temperature of thermoresponsive polymers,we demonstrated a strategy to control the multi-responsiveness of polymer assemblies via subtle modification of end groups of thermoresponsive polymer segments and revealed its potential application for drug delivery.By developing polymer assemblies composed of poly(aliphatic ester) as the inner core and thermoresponsive polyphosphoester as the outer shell,we showed that end groups of thermoresponsive polyphosphoester segments controlled the surface property of assemblies and further determined the stimuli-responsive behavior.The phase-transition temperatures of the unmodified polymer assemblies are tightly controlled by their surface properties due to the hydrophilic to hydrophobic transitions of end groups in response to an environmental stimulus (e.g.pH or light irradiation).External control over these surface properties can by asserted by adjusting the chemical structure and composition of the terminal groups of the thermoresponsive polyphosphoesters.

关 键 词：multi-responsive THERMORESPONSIVE PHASE-TRANSITION POLYPHOSPHOESTER 

分 类 号：TP393[自动化与计算机技术—计算机应用技术]