系统生物学技术在药源性肝损伤中应用的研究进展  

Research Advances in Drug- Induced Liver Injury Based on Systems Biology Technology

作　　者：吴骁[1,2] 陆益红[1,2] 汪玉馨[2,3] 汤道权[1] 樊夏雷[1,2] 

机构地区：[1]徐州医学院药物分析教研室,江苏徐州221004 [2]江苏省食品药品监督检验研究院,南京210008 [3]中国药科大学,南京210009

出　　处：《中国药学杂志》2014年第12期1009-1013,共5页Chinese Pharmaceutical Journal

摘　　要：目的药源性肝损伤(drug-induced liver injury,DILI)的临床表现和病理变化较为复杂,传统的临床生化指标不足以全面评价其发病机制,笔者综述近年来基于基因组学、蛋白质组学及代谢组学等系统生物学技术在肝毒性中的研究进展,为药源性肝损伤的预防、诊断、治疗提供依据。方法对近几年国内外采用不同组学技术研究肝损伤相关文献进行分析综述。结果与传统评价方法相比,系统生物学对于发现新型肝脏毒性生物标志物及探讨其形成机制更为全面,且准确度和灵敏度更高。结论基于基因组学、蛋白质组学、代谢组学的系统生物学技术将为肝毒性生物标记物的发掘及肝毒性诊断提供可靠的依据,将在药品肝毒性评价、机制研究及临床诊断等方面发挥重大的作用。OBJECTIVE To review the development of systems biology technology such as genomics, proteomics and metabonom- ics in hepatotoxicity research and may provide a reference for the prevention, diagnosis, treatment of DILI. METHODS Literatures about different omics in liver injury, which were published in recent years, were summarized and reviewed. RESULTS Compared with traditional methods, systems biology technology shows higher sensitivity and accuracy in finding the liver toxicity biomarkers and comprehensive formation mechanism. CONCLUSION Based on genomics, proteomics and metabonomics, systems biology technolo- gy will provide reliable evidences for the discovery of novel hepatotoxic markers and the diagnosis of hepatotoxicity. Therefore, systems biology technology may play a major role in hepatotoxicity assessment, hepatotoxicity mechanism research and clinical diagnosis in the future.

关 键 词：药源性肝损伤 系统生物学 基因组学 蛋白质组学 代谢组学 

分 类 号：R969[医药卫生—药理学]