人参皂苷对胃癌术后化疗患者血清VEGF的影响  

The effects of ginsenosides on Vascular Endothelial Growth Factor(VEGF) concentration of postoperative gastric cancer patients serum

作　　者：谢晓东[1] 朱永康[1] 

机构地区：[1]南京中医药大学附属医院普外科,江苏南京210029

出　　处：《中国肿瘤外科杂志》2014年第3期149-152,共4页Chinese Journal of Surgical Oncology

摘　　要：目的研究人参皂苷对胃癌术后患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)浓度的影响,评价人参皂苷对胃癌患者的治疗作用。方法以门诊浅表性胃炎患者30例为正常组,42例胃癌患者术后采用FOLFOX4方案化疗为对照组,另外52例胃癌患者术后除采用FOLFOX4方案化疗外,同时服用人参皂苷Rg3为实验组。分别比较正常组、对照组、实验组术前、术后1、3、6个月的血清VEGF浓度,并比较同一组别在不同时间点的血清VEGF浓度变化,并比较对照组及实验组术后6个月肿瘤复发情况以及复发患者与未复发患者血清VEGF浓度的差异。结果胃癌患者术前血清VEGF浓度显著高于正常组(P<0.01),对照组术后血清VEGF浓度显著下降,但仍显著高于正常组(P<0.05),而实验组术后6个月基本降至正常人群水平,显著低于对照组(P<0.05)。实验组术后6个月复发率为5.77%,显著低于对照组14.29%的复发率(P<0.05)。结论人参皂苷Rg3可明显降低胃癌患者术后血清VEGF浓度,抑制胃癌细胞的生长,并呈浓度、时间依赖关系,并降低胃癌术后患者的复发率。Objective To study the effects of ginsenosides on Vascular Endothelial Growth Factor （VEGF） concentration of postoperative gastric cancer patients serum and evaluate the treatment of patients with gastric cancer by ginsenosides. Methods Take 30 cases of superficial gastric cancer patients from outpatient as normal group, 42 cases of postoperative gastric cancer patients with FOLFOX4 chemotherapy as the control group, other 52 cases of postoperative gastric cancer patients taking FOLFOX4 chemotherapy and ginsenosides at the same time as the experimental group. The serum VEGF concentration of four groups was detected in different time （ one month, three months, six months） ,and compare the serum VEGF concentration change of same group at different given time, and compare patients of the control group and the experimental group with postoperative recurrence of tumor recurrence and no relapse patients serum VEGF concentration. Results Gastric cancer patients with preoperative serum VEGF concentration is significantly higher than normal group （P 〈 0. 01 ） , the control group of postoperative serum VEGF concentration decreased significantly, however, it is still significantly higher than normal group （ P 〈 0. 05 ）, while the experimental group after 6 months dropped to normal level, significantly lower than control group （ P 〈 0. 05 ）. Experimental postoperative recurrence rate was 5.77% 6 months later, the recurrence rate is 14. 29%, which was significantly lower than control group （ P 〈 0. 05 ） . Conclusions Ginsenosides Rg3 can obviously reduce postoperative gastric cancer patients serum VEGF concentration, inhibit the growth of gastric cancer cells, and reduce the postoperative recurrence rate on patients with gastric cancer.

关 键 词：人参皂苷 胃癌 血管内皮生长因子 化疗 

分 类 号：R735.2[医药卫生—肿瘤]