吉兰-巴雷综合征患者外周血Th17细胞和IL-23表达变化与其发病机制的相关性研究  

A study of the changes of Th17 cells and IL-23 in patients with Guillain-Barré syndrome

作　　者：何改平[1] 张彬[1] 张宝文[1] 乔梁杰 

机构地区：[1]天津市第四医院脑系科,300222

出　　处：《中国现代神经疾病杂志》2014年第6期526-530,共5页Chinese Journal of Contemporary Neurology and Neurosurgery

摘　　要：探讨吉兰-巴雷综合征患者外周血Th17细胞、血清和脑脊液IL-23表达变化在其免疫发病机制中的作用。流式细胞术和酶联免疫吸附试验显示,吉兰-巴雷综合征组患者外周血Th17细胞比例[(4.86±0.60)%]和血清IL-23水平[(111.80±13.84)pg/ml]均高于对照组[(2.71±0.54)%、(72.55±8.19)pg/ml],差异有统计学意义(t=2.616,P=0.012;t=2.300,P=0.026)。吉兰-巴雷综合征组患者经静脉注射免疫球蛋白后,血清和脑脊液IL-23水平恢复正常[(74.13±6.18)和(72.92±12.09)pg/ml],与治疗前[(110.50±15.66)和(102.30±7.52)pg/ml]相比,差异具有统计学意义(t=2.557,P=0.022;t=1.422,P=0.046)。吉兰-巴雷综合征患者外周血Th17细胞比例增加、血清和脑脊液IL-23水平升高,提示二者可能参与吉兰-巴雷综合征的发生与发展。Guillain- Barr6 syndrome （GBS） is an acute autoimmune- mediated inflammatory neuropathy. In this paper, the percentage of Thl7 in peripheral blood lymphocyte and the level of IL-23 in serum and cerebrospinal fluid （CSF） of patients with GBS were detected. Twenty-five patients with GBS and 20 controls were analyzed. The percentage of Thl7 cells in patients with GBS was （4.86 ± 0.60）%, which was higher than that in controls [（2.71 ± 0.54）%; t = 2.616, P = 0.012]. Serum IL-23 increased in patients with GBS [（111.80 ± 13.84）pg/ml vs （72.55±8.19） pg/ml; t = 2.300, P = 0.026]. The level of IL-23 in serum and CSF from patients with GBS before therapy [（110.50± 15.66i and （102.30 ±7.52） pg/ml] declined to normal after therapy [（74.13 ±6.18） and （72.92 ± 12.09） pg/ml], and the difference was statistically significant （t = 2.557, P = 0.022; t = 1.422, P = 0.046）. Th17 cells and IL-23 increased in patients with GBS, indicating that they may involve in the pathogenesis of GBS.

关 键 词：多发性神经根神经病 T淋巴细胞 辅助诱导 白细胞介素23 

分 类 号：R745.43[医药卫生—神经病学与精神病学]