基质金属蛋白酶2及CD147在卵巢上皮性肿瘤中的表达  

Expression of matrix metalloproteinase-2 and CD147 in ovarian epithelial tumor

作　　者：贺书云[1] 辛晓燕[1] 王健[1] 

机构地区：[1]第四军医大学西京医院妇产科,陕西西安710033

出　　处：《第四军医大学学报》2001年第5期435-438,共4页Journal of the Fourth Military Medical University

摘　　要：目的　了解基质金属蛋白酶 (MMP- 2 )及 CD147在卵巢良、恶性上皮性肿瘤中的表达 ,探讨其与卵巢癌转移发生的关系 .方法　用免疫组化 SP法对 47例卵巢癌组织、19例交界性上皮性卵巢肿瘤、17例良性上皮性卵巢肿瘤组织中MMP- 2及 CD147的表达情况进行了检测 .结果　MMP- 2在恶性及交界性上皮性卵巢肿瘤中的强阳性表达率分别为5 9% ,42 % ,明显高于良性组强阳性表达率 30 % (P<0 .0 5 ) ,在卵巢癌中 MMP- 2的表达与卵巢癌的临床分期有关 , ～ 期卵巢癌强阳性表达率 71% ,明显高于 ～ 期卵巢癌强阳性表达率 37% (P<0 .0 5 ) ,与分化程度无明显关联 ,但有淋巴结转移的病例强阳性表达率 87% ,明显高于无淋巴结转移组 .CD147在恶性及交界卵巢上皮性肿瘤中的强阳性表达率分别为 6 4% ,5 7% ,而良性组则未见 CD147的表达 .在卵巢癌中 ,CD147的强阳性表达率与临床分期有关 , ～ 期的癌组织强阳性表达率 74% ,明显高于 ～ 期强阳性表达率45 % ,在不同分化程度卵巢癌组织中 CD147的强阳性率无明显差异 ,有无淋巴结转移的卵巢癌组织中 CD147强阳性表达率差异显著 .结论　 MMP- 2及 CD147均与卵巢癌的分期及淋巴结转移有关 ,CD147与 MMP-AIM To investigate the expression of matrix metalloproteinase 2 (MMP 2) and CD147 in ovarian epithelialtumor. METHODS The expression of MMP 2 and CD147 was detected in malignant, borderline and benign ovarian tissues by immunohistochemical SP method. Monoclonal antibodies against MMP 2 and CD147 were used. RESULTS Intense expression rates of MMP 2 in the malignant, borderline, benign epithelial tumor tissues of ovary was 59%, 42%, 30% respectively, There were a significant difference between malignant, borderline and benign tumors ( P < 0.05 ). In ovarian cancer, the expression of MMP 2 had a significant relevance to clinical phases and lymph node metastasis. The intense expression rate (71%) in phases Ⅲ~Ⅳ of ovarian cancer was much higher than that in phases Ⅰ~Ⅱ (37%); no relevance was observed with pathological grades. The intense expression rates of CD147 in the malignant, borderline, benign ovarian epithelial tumor were 64%, 57%, 0 respectively. Significant difference was observed between malignant, borderline and benign ovarian epithelial tumor. In ovarian cancer, the expression of CD147 was associated with clinical phases; the intense expression rate (74%) in phases Ⅲ~Ⅳ of ovarian cancers was much higher than that in phases Ⅰ~Ⅱ (45%). 18 of 23 cases with lymph node metastasis had intense expression of CD147, while only 12 of 24 cases without lymph node metastasis had intense staining of CD147. No association was observed with pathological grades. CONCLUSION Both MMP 2 and CD147 have relevance to clinical phases and lymph node metastasis of ovarian cancer, but CD147 isn't the unique factor in increasing the expression of MMP 2 to contribute to the metastasis of ovarian cancer.

关 键 词：基质金属蛋白-2 CD147 卵巢肿瘤 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]