肺癌化疗前后血清SIL-2R、IL-6、TNF-α浓度变化及临床价值  

Clinical value of determination of changes of serum SIL-2r, IL-6 and TNF-α concentration of before and after chemotherapy in patients with lung cancer

作　　者：朱洪[1] 巫翠萍[1] 符火[1] 

机构地区：[1]海南医学院附属医院检验科,海口570102

出　　处：《中华临床医师杂志（电子版）》2014年第9期5-8,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的研究肺癌患者可溶性白细胞介素-2受体(SIL-2R)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的血清浓度变化对于肺癌的诊断和预后判断中的意义。方法选择100例肺癌患者作为试验组,选择同期健康体检的人群100例作为对照组,分别检测对照组及试验组化疗前后血清SIL-2R、IL-6、TNF-α浓度。结果试验组化疗前血清SIL-2R、IL-6和TNF-α浓度均明显高于对照组,并且差异具有统计学意义(P<0.05)。Ⅱ期患者的血清SIL-2R、IL-6和TNF-α浓度明显的低于Ⅲ期、Ⅳ期的患者,并且差异具有统计学意义(P<0.05)。试验组化疗后血清SIL-2R、IL-6和TNF-α浓度均较化疗前明显减少,并且差异具有统计学意义(P<0.05)。疗效为CR患者的血清SIL-2R、IL-6和TNF-α浓度明显低于PR、SD和PD,差异具有统计学意义(P<0.05)。结论检测肺癌患者血清SIL-2R、IL-6和TNF-α浓度变化可作为肺癌的诊断以及治疗预后判断的参考。Objective To investigate the clinical significance of changes of serum concentration of soluble interleukin-2 receptor（SIL-2R）, interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） before and after chemotherapy in patients with lung cancer. Methods One hundred of lung cancer patients were divided with experimental group, while one hundred healthy people were divided with control group. The concentration of serum IL-2R, IL-6 and TNF-αon the control group and the experimental group before and after chemotherapy were detected. Results The serum concentration of SIL-2R, IL-6 and TNF-αon the experimental group before chemotherapy were higher than on the control group,with significantly difference（P〈0.05）;the concentration of SIL-2R, IL-6 and TNF-αon patients of II state were lower than on the Ⅲ state andⅣstate, with significantly difference （P〈0.05）;after chemotherapy,the concentration of SIL-2R, IL-6 and TNF-α on the experimental group were decreased than before treatment, with significantly difference（P〈0.05）; the concentration of SIL-2R, IL-6 and TNF-α on the CR efficacy were lower than PR, SD and PD patients, with significantly difference（P〈0.05）. Conclusion The changes of levels of serum SIL-2R, IL-6 and TNF-αwere closely related to the diagnosis and were of prognostic value in lung cancer.

关 键 词：肺肿瘤 受体 白细胞介素2 白细胞介素6 肿瘤坏死因子Α 

分 类 号：R734.2[医药卫生—肿瘤]