CD4+T细胞在肿瘤免疫治疗中的应用进展  

The application of CD4 + T cells in tumor immunotherapy

作　　者：祝艳华[1] 尹良伟[1] 王苏平[1] 王颖[1] 于环[1] 

机构地区：[1]大连市中心医院细胞生物治疗科,辽宁大连116033

出　　处：《中国卫生产业》2014年第16期191-192,共2页China Health Industry

摘　　要：本文主要是为了研究CD4+T细胞在肿瘤免疫治疗中的应用进展,为肿瘤治疗提供可续依据。现如今,CD4+T细胞在肿瘤免疫治疗越来越受到人们的关注,CD4+T细胞可以通过IFN-y直接杀死肿瘤细胞,在此基础上能够激活CD8+T细胞以及CD4+T细胞;除此之外,CD4+T细胞可能被肿瘤表达的自身抗原所诱导,这可能与抗肿瘤应答的下调和肿瘤免疫耐受的维持有关,从而导致免疫治疗失败。本文对CD4+T细胞在肿瘤治疗中的重要性、具体作用和应用效果展开深入探讨,期望能有效提升肿瘤疫苗的临床效果。This paper is to study the application of CD4＋T cells in tumor immunotherapy progress, provide sustainable ba-sis for tumor treatment . Nowadays , CD4＋T cells in tumor immunotherapy more and more get the attention of people , CD4 ＋T cells can kill tumor cells directly by IFN-y , on the basis of that activate CD8＋T cells and CD4＋T cells; In addition , CD4＋T cells may be induced by tumor expression of autoantigen , this may be related to lower resistance to tumor response and tumor immune tolerance to maintain , resulting in immune treatment failure . In this paper , the importance of CD4＋T cells in tumor treatment , specific effects on in-depth discussion and application effect , expect can effectively improve the clinical effect of tumor vaccine .

关 键 词：CD4+T 细胞 肿瘤免疫 治疗 效果 

分 类 号：R730.54[医药卫生—肿瘤]