直肠癌旁移行粘膜维生素D受体的表达  

Expression of Vitamin D Receptor in the Transitional Mucosa Adjacent to the Rectal Carcinoma

作　　者：陈锦先[1] 唐伟军[1] 钟鸣[1] 王少华[1] 王平治[1] 吴志勇[1] 

机构地区：[1]上海第二医科大学仁济医院外科,上海200001

出　　处：《上海第二医科大学学报》2001年第2期134-136,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：目的探讨直肠癌旁移行粘膜 (TM )的性质。　方法采用免疫组化结合显微光度测量计算机图象分析技术 ,对 15例直肠癌旁移行粘膜及其癌组织中维生素D受体 (VDR)的表达与正常大肠粘膜进行比较。　结果直肠癌TM中VDR表达显著低于正常大肠粘膜 ;其表达介于癌组织与正常粘膜之间 ,与后二者差异均有显著性 (P <0 .0 5 )。TM中VDR的表达与病例的年龄、性别、Dukes分期、组织学分型、分化程度、肿瘤生长方式、浸润深度之间无统计上显著性的联系。癌旁TM的增殖指数显著高于正常粘膜。　结论直肠癌旁TM是一种早期癌前病变 ,在直肠癌手术中应予切除。Objective The aim of the study was to probe into the nature of the transitional mucosa(TM) adjacent to rectal carcinoma. 15 patients with rectal cancer were involved in this study. The vitamin D Receptor (VDR) expression of the tissue from tumor, transitional mucosa adjacent to rectal carcinoma and normal mucosa of the proximal resected margin were detected by imunohistochemistry, microspectrophotometer and computer image analysis. The VDR expression of the TM was significantly decreased compared to that of the normal mucosa, but significantly higher than that of the tumor tissue. There was no significant correlation of the VDR expression of the TM with sex, age, histological classification, Dukes stage, the way tumor grows, infiltration depth and differentiation grade of the cases. The Proliferation Index of the TM was more significantly increased than that of the normal mucosa. The TM adjacent to rectal carcinoma was a precancerous lesion and should be resected in the operation.

关 键 词：维生素D受体 直肠癌 移行粘膜 表达 DUKES分期 组织学分型 

分 类 号：R735.37[医药卫生—肿瘤]