人类白细胞抗原G在宫颈癌组织中的表达及临床意义  

Expression and clinical signifi cance of human leukocyte antigen G in cervical cancer

作　　者：王元芬[1] 牛子儒[1] 郭一帆[1] 谷芳[1] 刘忠宇[1] 姚元庆[1] 

机构地区：[1]解放军总医院妇产科,北京100853

出　　处：《解放军医学院学报》2014年第7期741-743,765,共4页Academic Journal of Chinese PLA Medical School

基　　金：北京市科技计划项目(Z131100006813023)~~

摘　　要：目的探讨人类白细胞抗原G(human leukocyte antigen G,HLA-G)在宫颈癌组织中的表达及其临床意义。方法应用S-P免疫组织化学方法检测于2006年1月-2011年12月就诊我院的98例宫颈鳞癌患者术后病理标本,并分析HLA-G的表达与病理参数之间的关系。结果 HLA-G分子在宫颈癌组织中表达率为43.9%(43/98),而在癌旁正常宫颈组织的表达率为0。HLA-G分子表达与淋巴结转移、脉管浸润有相关性(P<0.01)。结论 HLA-G分子在宫颈癌组织中表达上调,并与宫颈癌的侵袭性生长相关。HLA-G分子参与肿瘤细胞免疫逃逸过程,促进肿瘤的发生和发展。Objective To investigate the expression of HLA-G molecule in cervical cancer and its clinical significance. Methods Postoperative pathological samples of 98 patients with cervical cancer admitted to our hospital from January 2006 to December 2011 were detected by immunohistochemical method （S-P method）, and the relationship between HLA-G and clinico-pathological characteristics in cervical cancer was analyzed. Results The positive expression rate of HLA-G in cervical cancer was 43.9% （43/98）, while no positive expression was found in normal tissues. The expression of HLA-G was correlated with lymphatic metastasis and vascular invasion （P 〈 0.01）. Conclusion Expression of HLA-G in cervical cancer tissues is significantly higher than that in normal tissues and it relates to the invasive growth of cervical cancer. It is also suggested that HLA-G molecule is closely related to immune evasion which will also promote the development of tumor.

关 键 词：宫颈癌 人类白细胞抗原G 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]