116例成人急性非早幼细胞髓系白血病预后因素分析  

Prognostic factors analysis in 116 cases of adult acute non- APL myeloid leukemia

作　　者：温娟娟[1] 柳金[1] 许蕾[1] 孙丽华[1] 钟凤鸾[1] 孟庆祥[1] 

机构地区：[1]北京大学深圳医院血液科,深圳518116

出　　处：《工企医刊》2014年第3期743-744,共2页The Medical Journal of Industrial Enterprise

摘　　要：目的探讨成人急性髓系白血病(非APL)预后相关因素。方法回顾性分析北大深圳医院血液内科116例初发AML患者临床特征:年龄、初发WBC水平、骨髓细胞免疫表型特征与预后关系。结果完全缓解(CR)率:总CR率70.7%(82/116),≥60岁组58.6%(17/29),显著低于<60岁组74.7%(65/87);初发WBC≥30×109/L组52.2%(25/48),显著低于<30×109/L组83.8%(57/68);CD34阳性组59.7%(40/67),低于CD34阴性组85.7%(42/49);2年复发率:CD34阳性组76.0%(19/25),显著高于CD34阴性组14.3%(3/18)。多因素分析:≥60岁、初发WBC≥30×109/L是CR率的独立危险因素;CD34阳性是2年复发率的独立危险因素;CD34阳性是长期生存的独立危险因素。结论 CD34阳性是复发率、长期生存的独立危险因素。Objective ： To analyze the prognostic factors of adult acute non - APL myeloid leukemia. Methods ： 116 cases of initial AML in Peking University Shenzhen hospital in - patient department were retrospective analyzed. The clinical information for prognosis included： gender, age, WBC level at diagnosis and immunophenotyping. Result： CR rates： The overall rate was 70.7% （82/116）. The rate of ≥60 year old patients was 58.6% （17/ 29）, significantly lower than 〈 60 year old patients, 74.7% （65/87）. The rate of WBC at diagnosis 〉130 × 10^9/L patients was 52.2% （25/48）, significantly lower than 〈 30 × 10^9/L patients, 83.8% （57/68）. The rate of CD34 positive patients was 59.7% （40/67）, lower than CD34 negative patients, 85.7% （42/49）. Recurrent rates in 2 years： the rate of CD34 positive patients was 76.0% （ 19/25）, significantly higher than CD34 negative patients, 14.3% （3/18）. Multiple factor analysis ： ≥ 60 year old, WBC at diagnosis ≥ 30 × 10^9/L were independent risk factors of CR rate. CD34 positive was independent risk factor of recurrence. CD34 positive was independent risk factor of long - term survival. Conclusion ： CD34 positive was independent risk factor of recurrence and long - term survival.

关 键 词：急性 髓系白血病 非APL 年龄 WBC水平 CD34 预后 

分 类 号：R733.71[医药卫生—肿瘤]