复合螺旋藻多糖对S180荷瘤小鼠免疫功能的影响  

Effects of Compound Polysaccharides from Spirulina Platensis on Immunity Function of S180 Tumor-bearing Mice

作　　者：刘永举[1] 贾玉辉[1] 唐超[1] 葛蔚[1] 王清吉[1,2] 

机构地区：[1]青岛农业大学生命科学学院,山东青岛266109 [2]山东省高校植物生物技术重点实验室

出　　处：《青岛农业大学学报（自然科学版）》2014年第1期27-30,共4页Journal of Qingdao Agricultural University(Natural Science)

基　　金：山东省自然科学基金(No.ZR2009EM009)

摘　　要：将螺旋藻多糖(PSP)与银杏提取物(GBE)按11比例配制成复合螺旋藻多糖。昆明种小白鼠随机分为5组(荷瘤对照组、阳性对照组、低剂量组、中剂量组、高剂量组),灌服复合螺旋藻多糖,检测复合制剂对S180荷瘤小鼠免疫功能的影响。结果表明:与对照组相比,灌服低剂量组、中剂量组和高剂量组复合螺旋藻多糖:荷瘤小鼠的碳廓清系数分别提高了13.605%,53.061%,112.930%(p<0.01);吞噬指数分别提高了9.9665%,14.7650%,26.7220%(p<0.01);淋巴T细胞增殖率分别提高了30.47%,41.89%,87.66%(p<0.01);白细胞介素-6含量分别降低了60.19%、62.92%和69.42%(p<0.01)。由此说明:复合螺旋藻多糖对S180荷瘤小鼠单核巨噬细胞的吞噬能力和淋巴T细胞的增殖转化能力有明显促进作用,并能明显降低IL-6的含量水平。The polysaccharides from Spirulina Platensis （PSP）was compounded with the efective ingredients of Ginkgo Biloba（GBE） at the ratio of 1：1 .The KunMing rats were randomly divided into 5 groups （tumor-bearing group ,positive control group ,low-dose group ,mediate-dose group ,high-dose group） ,fed with compound polysaccharides from spirulina platensis . Test the effects of compound polysaccharides from spirulina platensis on the immunity function of S 180 tumor-bearing mice .Result ：compared with the tumor-bearing group ,the carbon clearance coefficient of low-dose group ,mediate-dose group and high-dose group raised 13.605% ,53.061% and 112.93% （p 〈 0.01 ） respectively ,the swallowing index of these groups reduced 9.9665% ,14.765% ,26.722% （p〈 0.01 ）respectively ,the ratio of replication of T lymph cell of these groups raised 30.47% ,41.89% ,87.66% （p〈0.01） ,the content of IL-6 of these groups re-duced 60.19% ,62.92% ,69.42% （p〈0.01） .The compound polysaccharides from spirulina platensis had obviously enhanced the swallowing ability of Mononuclear macrophages and the proliferation reaction of T lymphocyte of S180 tumor-bearing mice ,reduced the content of IL-6 .

关 键 词：复合螺旋藻多糖 S180荷瘤小鼠 免疫功能 

分 类 号：R733[医药卫生—肿瘤]