柠檬苦素类化合物对人乳腺癌细胞(MCF-7)的生长抑制及细胞周期动力学的影响  

The Effect of Limonoid on the Growth-Inhibition and Cell Cycle of Human Mammary Cancer Cell Line(MCF-7)

作　　者：唐莉莉[1] 曾祥斌[2] 田庆国[1] 丁霄霖[1] 

机构地区：[1]无锡轻工大学食品学院,江苏无锡214036 [2]上海医科大学公共卫生学院,上海200032

出　　处：《无锡轻工大学学报（食品与生物技术）》2001年第2期205-207,共3页Journal of Wuxi University of Light Industry

摘　　要：为了探讨柠檬苦素类似物对乳腺癌细胞MCF 7生长抑制和对细胞周期的影响 ,应用MTT法和流式细胞仪检测癌细胞株生长和细胞周期 .结果显示柠檬苦素类似物能明显抑制MCF 7的生长 ,抑制率高于 70 % ,并随作用时间和剂量增加其效果增强 ;柠檬苦素可以影响细胞周期G2 /M期 .柠檬苦素类似物可以明显抑制MCF 7的增殖 ,并有可能是通过阻滞细胞在G2 /M期而降低其生长能力 .To explore the effect of Limonoid on the growth inhibition and cell cycle of human mammary cancer cell lines (MCF 7), the growth and cell cycle of MCF 7 were detected by MTT assay and FCM. The Limonoid can inhibit the growth of MCF 7. The rate of inhibition was morn than 70 percent and related to does and times. The cells show G 2/ M arrest. Limonoid has effects on inhibiting MCF 7, and the mechanism of action may be associated with influence of the G 2/ M arrest.

关 键 词：柠檬苦素类似物 乳腺癌细胞 生长抑制 细胞周期 动力学 

分 类 号：R737.9[医药卫生—肿瘤]