血浆硫氧还蛋白还原酶在肺癌中表达的初步研究  

Activity of plasma thioredoxin reductase activity in lung cancer: A preliminary study

作　　者：李方超[1] 曾慧慧[2] 李贵新[3] 黄琰[3] 傅玲[3] 

机构地区：[1]潍坊医学院肿瘤学教研室,山东潍坊261053 [2]北京大学药学院,北京100083 [3]潍坊医学院附属医院肿瘤科,山东潍坊261031

出　　处：《实用肿瘤杂志》2014年第3期231-233,共3页Journal of Practical Oncology

摘　　要：目的探讨血浆硫氧还蛋白还原酶(thioredoxin reductase,TrxR)在肺癌中的活性表达及临床意义。方法酶联免疫分析方法检测50例肺癌患者及50例健康体检者血浆中TrxR的活性表达,并作相关分析。结果肺癌患者血浆中TrxR活性高于健康体检者,且差异有统计学意义(P<0.05);肺腺癌、肺鳞癌、小细胞肺癌患者血浆TrxR活性均值分别为(3.96±5.22)U/mL、(6.31±6.20)U/mL、(6.98±7.04)U/mL,各组间TrxR活性水平差异无统计学意义(P>0.05)。结论 TrxR活性表达与肺癌密切相关。TrxR活性表达在肺癌不同组织学分型间相同。Objective To investigate thioredoxin reductase （TrxR） activity in lung cancer and its clinical significance. Methods Plasma TrxR activity was detected in 50 cases of lung cancer and 50 healthy subjects. Results TrxR activity in the plasma of patients with lung cancer was significantly higher than that of healthy subjects （P 〈 0.05 ）. The average TrxR activity levels of lung adenocarcinoma, squamous cell carcinoma, small cell lung cancer were （ 3.96 ±5.22） U/mL, （6.31 ±6.20） U/mL and （6.98 ±7.04） U/mL （ P 〉 0.05 ）. Conclusion Plasma TrxR activity is higher in lung cancer and it is not different in various histological types of lung cancer.

关 键 词：肺肿瘤 硫氧还蛋白质类 生物合成 硫氧还蛋白二硫化物还原酶 生物合成 细胞存活 癌 小细骨包 血液 肿瘤标记 生物学 随机分配 

分 类 号：R734.2[医药卫生—肿瘤]