人类真核延伸因子1A2与生长因子受体结合蛋白2在胰腺癌组织中的表达及临床病理意义  

Clinicopathologic significance of expression of EEF1A2 and GRB2 in pancreatic adenocarcinoma

作　　者：周维霞[1] 蒋晓红[1] 杨勇[1] 陈瑞东[1] 胡端敏[1] 

机构地区：[1]苏州大学附属第二医院消化科,江苏省苏州市215004

出　　处：《世界华人消化杂志》2014年第14期2049-2054,共6页World Chinese Journal of Digestology

摘　　要：目的:探讨人类真核延伸因子1A2(eukaryotic elongation factor 1A2,EEF1A2)和生长因子受体结合蛋白2(growth factor receptor-bound 2,GRB2)在胰腺癌组织中的表达、相互关系及临床病理意义.方法:应用免疫组织化学方法检测97胰腺癌及其周边胰腺组织中EEF1A2和GRB2蛋白表达情况.结果:EEF1A2蛋白在胰腺癌周边组织中不表达,但在77.8%(76/97)的胰腺癌组织中表达阳性.EEF1A2的异常表达与胰腺癌周边淋巴结转移(χ2=4.28,P=0.039)和神经浸润显著相关(χ2=4.11,P=0.043).GRB2蛋白在胰腺癌和周边胰腺组织中阳性表达率分别为82.5%(80/97)和30.2%(31/97),胰腺癌组织中GRB2蛋白阳性率显著高于周边胰腺组织(χ2=48.5,P<0.001).GRB2阳性表达率与淋巴结转移显著相关(χ2=4.63,P=0.031).胰腺癌中EEF1A2和GRB2表达具有显著等级正相关(rs=0.451,P<0.001).结论:EEF1A2和GRB2的表达与胰腺癌的生物学行为密切相关,且两者之间的表达强度具有显著等级正相关.AIM： To investigate the expression of eukaryotic elongation factor1A2（EEF1A2） and growth factor receptor-bound 2（GRB2） in pancreatic adenocarcinoma（PA） and to analyze their clinicopathologic significance. METHODS： Expression of EEF1A2 and GRB2 was examined by immunohistochemistry in 97 PA specimens and surrounding pancreatic tissues. RESULTS： EEF1A2 expression was absent in normal pancreatic tissue. In contrast, EEF1A2 showed positive immunoreactivity in 77.8%（76/97） of PA cases. The increased eEF1A2 ex-pression was significantly associated with the presence of nodal metastasis（χ2 = 4.28, P = 0.039） and perineural invasion（χ2 = 4.11, P = 0.043）. The expression rate of GRB2 in 97 PA specimens and surrounding pancreatic tissues were 82.5%（80/97） and 30.2%（31/97）, respectively. The expression level of GRB2 in PA was significantly higher than that in surrounding pancreatic tissues（χ2 = 48.5, P 0.001）. The positive rate of GRB2 expression was significantly correlated with lymph node metastasis（χ2 = 4.63, P = 0.031）. There was a positive expression between the expression of EEF1A2 and that of GRB2 in PA（rs = 0.451, P 0.001）. CONCLUSION： The expression of GRB2 and EEF1A2 is closely correlated with the biological behavior of PA. The expression of GRB2 is significantly correlated with that of EEF1A2.

关 键 词：胰腺癌 人类真核延伸因子1A2 生长因子受体结合蛋白2 转移 

分 类 号：R735.9[医药卫生—肿瘤]