结直肠癌的表观遗传学  

Epigenetics of colorectal cancer

作　　者：剧宏燕[1] 柴秀坤 白文元[1] 

机构地区：[1]河北医科大学第二医院消化内科,河北省石家庄市050000

出　　处：《世界华人消化杂志》2014年第15期2128-2133,共6页World Chinese Journal of Digestology

摘　　要：结直肠癌是常见的消化系恶性肿瘤,他的发生是基因突变和表观遗传学改变逐渐积累、共同作用的结果.且表观遗传学的作用比基因突变的作用更大.本文论述了结直肠癌中表观遗传学的研究进展,为结直肠癌的预防、诊断、治疗及预后提供新的思路.Colorectal cancer is a common type of gastroin- testinal cancer with high incidence. It is generally considered that colorectal cancer develops through a multistep process that results from the progressive accumulation of mutations and epigenetic changes. The genes in colorectal cancer are more frequently affected by altered epigenetics than by mutations. In this review, we will discuss epigenetic changes of colorectal cancer, aiming to provide new ideas for the prevention, diagnosis, treatment and prognosis of this malignancy.

关 键 词：结直肠癌 DNA甲基化 组蛋白修饰 染色质重塑 非编码RNA调控 

分 类 号：R735.3[医药卫生—肿瘤]