戊型肝炎病毒疫苗作为人乳头状瘤病毒疫苗效果评价对照组的可行性及血清抗体危险因素分析  

Feasibility of HEV vaccine as control in HPV vaccine study and comparison of serological and risk factors between HEV and HPV infection among females

作　　者：崔剑峰[1] 杜旌畅 费满冬[1] 何微[1] 张韶凯[1] 游嘉[1] 司玉芝 樊小平 陈汶[1] 

机构地区：[1]中国医学科学院北京协和医学院肿瘤医院肿瘤研究所流行病学研究室,100021 [2]河南省新密市妇幼保健院检验科

出　　处：《中华肿瘤杂志》2014年第6期476-480,共5页Chinese Journal of Oncology

摘　　要：目的研究女性人群戊型肝炎病毒抗体（HEV-IgG）和人乳头状瘤病毒抗体（HPVL1-IgG）的分布情况以及危险因素，探讨HEV疫苗免疫人群作为HPV疫苗人群免疫效果评价对照组的可行性。方法对河南省新密地区952例女性人群进行筛查研究，通过问卷调查获得其人口学特征与危险因素。取每名受试者9ml外周血，采用酶联免疫吸附方法检测同一研究对象HEV-IgG和HPVL1．IgG的水平。采用Logistic回归分析的方法描述影响HEV-IgG与HPVL1-IgG表达的危险因素。结果研究人群的平均年龄为47．2岁，农民所占的比例为85．8％，低收人人群占44．5％。952例研究人群中，HPVL1-IgG的阳性率为26．8％（255／952），HEV-IgG的阳性率为31．0％（295／952），HEY-IgG与HPVL1-IgG的表达无关（P=0．749）。HEV-IgG与HPVL1-IgG的表达水平基本随年龄增长而升高，不同年龄组的表达差异有统计学意义（均P〈0．001）。多因素分析显示，年龄（OR=1．050，95％CI为1．031-1．069）、是否为低收入人群（OR=1．341，95％CI为1．004-1．790）、是否为农民（OR=0．604，95％CI为0．402～0．906）为HEV-IgG阳性影响因素；年龄（OR=1．022，95％C1为1．001-1．043）、初次性生活年龄（OR=0．923，95％C1为0．861～0．990）、是否接受过教育（OR：0．630，95％CI为0．423-0．939）为HPVL1-IgG阳性影响因素。结论新密地区女性人群HEV-IgG与HPVL1-IgC的阳性率基本随年龄增长而升高；年龄是HEV-IgG与HPVL1-IgG的共同危险因素；HEV-IgG与HPVL1-IgG的检测未见交叉反应。Objective Investigating the distribution of anti-hepatitis E virus （HEV-IgG）, anti- human papillomavirus （HPV LI-IgG） and risk factors among female residents in Xinmi County, to explore the influencing factors of HPV vaccine study using HEV vaccinated population as a control. Methods A screening study of cervical cancer in Xinmi County, Henan Province, was performed. The information of demographic characteristics and risk factors was collected using standard questionnaire. Nine ml blood was drawn from each woman for enzyme-linked immunosorbent assay to detect HEV-IgG and HPV LI-IgG antibody. Percentile, histogram and binary logistic regression model were used to describe the distribution of risk factors and their correlation to HPV and HEV infection. Results The average age of the Xinmi female residents was 47.2 years, their positive rate of HPV L1 antibody was 26.8% , and that of HEV-IgG antibody was 31.0% , both of which were raised with age （ P 〈 0. 001 ）. Single factor analysis showed that non- education, low-income and growing age were associated with HEV-IgG antibody positivity, and non- education, lowering ages of first sexual life and growing age were associated with HPV LI-IgG antibodypositivity. Multivariable analysis showed that growing age, low-income and work as peasantry were ii^dependent risk factors for HEV-IgG antibody positivity, and lowering ages of first sexual life, non-education and growing age were independent risk factors for HPV LI-IgG antibody positivity. Conclusions Both the HEV-IgG and HPV LI-IgG antibodies positive rates increase with age. Age is the common risk factor of HEV-IgG and HPV LI-IgG antibodies in female residents in Xinmi County. The risk factors of HEV-IgG and HPV LI-IgG antibodies have no statistical association, neither cross reaction was found in the HEV-IgG and HPV LI-IgG detection.

关 键 词：宫颈肿瘤 戊型肝炎病毒抗体 人乳头状瘤病毒抗体 酶链免疫吸附试验 危险因素 

分 类 号：R737.9[医药卫生—肿瘤]