Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization(HePI) mass spectrometry  

作　　者：Athula B.Attygalle Freneil B.Jariwala Julius Pavlov Zhihua Yang Jason A.Mahr Mabel Oviedo 

机构地区：[1]Center for Mass Spectrometry,Department of Chemistry,Chemical Biology,and Biomedical Engineering,Stevens Institute of Technology [2]Montville Township High School [3]North Bergen High School

出　　处：《Journal of Pharmaceutical Analysis》2014年第3期166-172,共7页药物分析学报（英文版）

基　　金：supported by the Project SEED Summer Research Program of the American Chemical Society

摘　　要：A simple modification converts an electrospray ion source to an ambient-pressure helium plasma ionization source without the need of additional expensive hardware. Peaks for active ingredients were observed in the spectra recorded from intact pharmaceutical tablets placed in this source. A flow of heated nitrogen was used to thermally desorb analytes to gas phase. The desorption temperatures were sometimes as low as 50 ℃. For example, negative-ion spectra recorded from an aspirin tablet showed peaks at m/z 137 （salicylate anion） and 179 （acetylsalicylate anion） which were absent in the background spectra. The overall ion intensity increased as the desorption gas temperature was elevated. Within the same acquisition experiment, both positive- and negative-ion signals for acetaminophen were recorded from volatiles emanating from Tylenol tablets by switching the polarity of the capillary back and forth. Moreover, different preparations of acetaminophen tablets could be distinguished by their ion-intensity thermograms.A simple modification converts an electrospray ion source to an ambient-pressure helium plasma ionization source without the need of additional expensive hardware. Peaks for active ingredients were observed in the spectra recorded from intact pharmaceutical tablets placed in this source. A flow of heated nitrogen was used to thermally desorb analytes to gas phase. The desorption temperatures were sometimes as low as 50 ℃. For example, negative-ion spectra recorded from an aspirin tablet showed peaks at m/z 137 （salicylate anion） and 179 （acetylsalicylate anion） which were absent in the background spectra. The overall ion intensity increased as the desorption gas temperature was elevated. Within the same acquisition experiment, both positive- and negative-ion signals for acetaminophen were recorded from volatiles emanating from Tylenol tablets by switching the polarity of the capillary back and forth. Moreover, different preparations of acetaminophen tablets could be distinguished by their ion-intensity thermograms.

关 键 词：Helium plasma ionization Pharmaceutical tablets HePI DART DESI 

分 类 号：R927[医药卫生—药学]