Pentacam与SL-OCT测量对原发性闭角型青光眼患者激光周边虹膜切开手术前后中央前房深度的相关性分析  

Evaluation of central anterior chamber depth before and after laser peripheral iridoplasty in primary angle-closure glaucoma by Pentacam and SL-OCT

作　　者：许多[1] 朱晓燕[1] 刘李娜[1] 陈侠[1] 王薇[1] 阚秋霞[1] 谢琳[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所眼科,重庆400042

出　　处：《第三军医大学学报》2014年第12期1327-1330,共4页Journal of Third Military Medical University

摘　　要：目的 评估Pentacam与SL-OCT测量原发性闭角型青光眼（primary angle-closure glaucoma，PACG）应用激光周边虹膜切开术（laser peripheral iridoplasty，LPI）手术前后中央前房深度（center anterior chamber depth, CACD）的差异性、相关性和一致性。方法 在我院眼科门诊筛查PACG患者中符合行LPI术的病例共58例（58眼），应用眼前节分析系统Pentacam和裂隙灯光学相干断层成像术（slit-lamp-adapted optical coherence tomography, SL-OCT）分别对PACG患者进行CACD测量，分别记录LPI术前，术后1 d、1周、1个月参数。结果 Pentacam测得PACG患者LPI术前，术后1 d、1周及1个月的CACD分别为（1.60±0.31）、（1.65±0.28）、（1.62±0.30）、（1.61±0.31）mm。SL-OCT测量LPI术前，术后1 d、1周及1个月的CACD分别为（1.70±0.30）、（1.73±0.30）、（1.71±0.31）、（1.72±0.31）mm。2种测量方式LPI术前与术后各时间比较，差异均无统计学意义（P〉0.05）；而2种测量方式之间相比较，术前及术后相同时间点差异均具有统计学意义（P〈0.01）。Pentacam与SL-OCT测量PACG患者LPI术前，术后1 d、1周及1个月的CACD值均存在显著相关关系（r=0.929，P〈0.001；r=0.962，P〈0.001；r=0.961，P〈0.001；r=0.951，P〈0.001）。通过Bland-Altman分析方法，Pentacam与SL-OCT测量LPI术前，术后1 d、1周及1个月CACD差异的95%置信界限分别为-0.33～0.12、-0.29～0.08、-0.25～0.08、-0.26～0.07 mm。结论 Pentacam与SL-OCT测量PACG患者LPI术后CACD具有高度一致性和相关性，二者均可作为青光眼临床筛查的辅助检查方式，为患者提供了有效的无创且可量化的便捷检查。Objective To evaluate the central anterior chamber depth （CACD） before and after laser peripheral iridoplasty （LPI） in patients with primary angle-closure glaucoma （PACG）, and assess the difference, relevance and consistency between Pentacam and slit-lamp-adapted optical coherence tomography （SL-OCT） in measuring CACD. Methods A total of 58 PACG patients （58 eyes） were enrolled in this study. Pentacam anterior segment analysis system and Heidelberg SL-OCT were used separately before and in 1 d, 1 week, and 1 month after LPI to measure the CACD in all patients. Results The mean CACD values of PACG before and in 1 d, 1 week, and 1 month after LPI measured by Pentacam were 1.60±0.31, 1.65±0.28, 1.62±0.30, and 1.61±0.31mm, respectively, while those measured by SL-OCT were 1.70±0.30, 1.73±0.30, 1.71±0.31, and 1.72±0.31 mm, respectively. Using the 2 methods, no statistical differences was observed in the CACD values before and after LPI in PACG （P〉0.05）. Significant differences of CACD values, however, existed between the 2 methods at all time points （P〈0.01）. Good correlations were found between Pentacam and SL-OCT before and in 1 d, 1 week, and 1 month after LPI （r=0.929, P〈0.001; r=0.962, P〈0.001; r=0.961, P〈0.001; and r=0.951, P〈0.001, respectively）. By Bland-Altman analysis, the 95% limits of differences between Pentacam and SL-OCT before and in 1 d, 1 week, and 1 month after LPI were -0.33 to 0.12, -0.29 to 0.08, -0.25 to 0.08, and -0.26 to 0.07 mm, respectively. Conclusion In PACG, Pentacam and SL-OCT, of good consistency and correlation in measuring CACD, can be both used for glaucoma screening, and provide an effective non-invasive and quantitative way for patients.

关 键 词：PENTACAM 裂隙灯光学相干断层成像术 原发性闭角型青光眼 中央前房深度 激光虹膜周切术 

分 类 号：R770.43[医药卫生—眼科] R775.2[医药卫生—临床医学]