丹参酮ⅡA联合神经节苷脂治疗外伤性脑梗死的疗效观察  

Efficacy of TanshinoneⅡA combined ganglioside in the treatment of traumatic cerebral infarction

作　　者：莫一丽 覃桦荣 

机构地区：[1]广西藤县人民医院,藤县543300

出　　处：《中国实用神经疾病杂志》2014年第11期16-18,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨丹参酮ⅡA联合神经节苷脂治疗外伤性脑梗死的临床疗效。方法将126例外伤性脑梗死患者按照入院先后分为观察组和对照组各63例。对照组采用神经节苷脂治疗,观察组采用丹参酮ⅡA联合神经节苷脂治疗。治疗14d后,比较2组的疗效和日常生活能力评分状况,评价联合用药的临床价值。结果观察组痊愈、显效、有效和无效分别有15、35、9和4例,总有效率为93.65%,对照组为80.95%,观察组总有效率显著高于对照组(P<0.05)。2组日常生活能力较治疗前均明显提升(P<0.05)。观察组治疗后Barthel指数评分75.2±14.6,对照组为51.7±13.8,观察组明显优于对照组(P<0.05)。2组在不良反应发生方面比较差异无统计学意义(P>0.05)。结论丹参酮ⅡA联合神经节苷脂治疗外伤性脑梗死可有效提升治疗效果,改善患者日常生活能力,未增加不良反应。Objective To investigate the clinical therapeutic value of Tanshinone Ⅱ A combined ganglioside in the treatment of traumatic cerebral infarction. Methods One hundred and twenty-six traumatic cerebral infarction patients were selected and were divided into control group and observation group according to the time of admission. The control group received ganglioside treatment ,while observation group acceptd Tanshinone Ⅱ A combined ganglioside treatment.At the 14 d after treatment ,the efficacy and activities of daily living score position were compared to evaluate the clinical value of combination therapy. Results The cure ,effective ,effective and ineffective number of cases were 15 ,35 ,9 and 4 cases ,respectively ,and the total effective rate reached 93.65% ,which was significantly higher than that in control group （P〈0.05）. Compared with that before treatment ,the daily living activities of both 2 groups improved significantly （P〈0.05）. After the treatment ,the Barthel index score of observation group and control group were 75.2 ± 14.6 and 51.7 ± 13.8 ,respectively ,there was significant difference between the two groups （P〈0.05）. For the incidence of adverse reactions ,two groups showed no significant difference （P〉0.05）. Conclusion Tanshinone ⅡA combined ganglioside for treatment of traumatic cerebral infarction can enhance the therapeutic effect ,improve the ability of daily lives without increasing adverse reactions.

关 键 词：丹参酮ⅡA 神经节苷脂 外伤性脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]