基因印记与精子发生障碍的研究进展  

Research Advance on Genomic Imprinting and Spermatogenesis Dysfunction

作　　者：王思梦[1] 宋杨[1] 吴南翔[1] 

机构地区：[1]浙江省医学科学院,浙江310013

出　　处：《环境与职业医学》2014年第6期486-489,共4页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金资助项目(编号:81102161);浙江省自然科学基金(编号:LY14H260004);浙江省医药卫生科技计划(编号:201475777)

摘　　要：基因印记是特定基因的一对等位基因发生差异性的表达,机体仅表达来自亲本一方的等位基因,而另一方保持沉默。精子发生是一个高度复杂的独特分化过程,包括精原细胞发育为精母细胞、单倍体精细胞的形成和精子成熟。本文通过探讨精子发生障碍与基因印记的关系,分析不育男性表观遗传缺陷的潜在风险,为临床男性不育的预防和治疗提供理论支持。Genomic imprinting is a mechanism that regulates monoallelic gene expression in a parental origin-dependent way. Spermatogenesis is a highly complex and unique differentiation process that involves development of spermatogonia into spermatocytes, formation of haploid spermatid, and maturation of spermatozoa. This review aimed to discuss the relationship between spermatogenesis disorder and genomic imprinting, evaluate the potential risks of epigenetic defects in the infertile men, and provide theoretical evidence for clinical treatment of male infertility.

关 键 词：基因印记 DNA甲基化 精子发生 表观遗传缺陷 综述 

分 类 号：Q786[生物学—分子生物学] Q954.43