鸦胆子油乳对晚期结直肠癌患者疗效和生存质量的影响  

Curative effect and efficacy of life quality of bruceolic oil emulsion's on the patients with advanced colorectal carcinoma

作　　者：包向东[1] 崔焌辉[1] 潘海强[1] 张瑛[2] 吴美倩[2] 赵军超[3] 沈燕[3] 

机构地区：[1]浙江省立同德医院肛肠科,杭州310012 [2]浙江省立同德医院中医科,杭州310012 [3]海盐县中医院,浙江海盐314300

出　　处：《中国临床药理学杂志》2014年第6期497-499,502,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价鸦胆子油乳对晚期结直肠癌疗效和生存质量的影响。方法晚期结直肠癌患者130例随机分为治疗组和对照组,各65例,治疗组用鸦胆子油乳联合奥沙利铂+亚叶酸钙+氟脲嘧啶(mFOLFOX6)方案治疗,对照组仅用mFOLFOX6方案治疗,比较2组的客观缓解率(ORR)、疾病控制率(DCR)、肿瘤进展时间(TTP)、毒副反应和Karnofsky功能状态评分(KPS)、生活质量评分(QOL)。结果可评价患者125例,其中治疗组63例,对照组62例。治疗组的ORR、TTP高于对照组[65.08%vs 41.94%,P<0.05;(13.49±3.90)个月vs(9.26±4.66)个月,P<0.01)],KPS评分、QOL改善均显著优于对照组(P<0.01);骨髓抑制发生率低于对照组(42.86%vs 69.35%,P<0.01);2组DCR及在胃肠道反应和神经不良反应差异无统计学意义(均P>0.05)。结论加用鸦胆子油乳治疗晚期结直肠癌可提高临床疗效,延长TTP,改善生存质量,减轻骨髓抑制。Objective To evaluate the effect of bruceolic oil emulsion on the advanced colorectal carcinoma and life quality of patients. Methods One hundred and thirty patients with advanced colorectal cancer were randomly divided into treatment group （n = 65 ） and control group （ n = 65）. The patients in treatment group were treated with bruceolic oil emulsion combined with mFOLFOX6, and those in the control group only with mFOLFOX6. The objective response rate （ORR） ,disease control rate （DCR）, time to tumor progression （TYP）, toxicities and Karnofsky scores （KPS） , and quality of life scores（QOL）in two groups were compared. Resultes The 125 evaluable patients were assigned into the treatment group （ 63 patients ） and the control group （ 62 patients ）. The ORR and TIP in the treatment group were higher than in the control group [65.08% vs 41.94%,P 〈0.05; （13.49 ±3.90） months vs （9.26 ±4.66） months,P 〈 0. 01 ） ]. The treatment group was significandy superior to the control group in KPS and QOL （ P 〈 0. 01 ）. The occurrence of bone marrow suppression was significantly lower than that in the control group （42. 86% vs 69.35% ,P 〈0. 01 ）. There were no significant differences between the two groups in DCR （77.77% vs 72.59%, P 〉 0. 05 ）, gastrointestinal reactions and neurotoxicity（P 〉 0. 05 ）. Conclusion Bruceolic oil emulsion could improve the clinical curative effect, extend TTP, improve the life quality of patients and decrease marrow suppression in treating advanced colorectal carcinoma.

关 键 词：鸦胆子油乳 晚期结直肠癌 客观缓解率 疾病控制率 

分 类 号：R735.3[医药卫生—肿瘤] R969.4[医药卫生—临床医学]