PDMS-PU/ST复合微球的制备及其性能研究  

Research on synthesis and performance of PDMS-PU/ST complex microspheres

作　　者：杨延慧[1] 严涵[1] 李芳霞[1] 卢金富 胡青松[1] 陈晓浪[2] 张志斌[1] 周先礼[1] 

机构地区：[1]西南交通大学生命科学与工程学院,成都610031 [2]西南交通大学材料科学与工程学院,成都610031

出　　处：《化工新型材料》2014年第6期46-48,共3页New Chemical Materials

基　　金：国家自然科学基金资助项目(51003088;50573061);教育部新世纪优秀人才支持计划(NECT-08-0820);中央高校基本科研业务费专项资金资助(2010ZT09;SWJTU09CX062)

摘　　要：采用预聚-扩链-中和-分散法合成了端羟基聚二甲基硅氧烷(DHPDMS)改性聚氨酯(PU)水溶液,再将PU水溶液和淀粉(ST)溶液按照不同的质量比进行复合,采用凝聚相分离法制备出PDMS-PU/ST复合微球;考察了PEG分子量、n(-OH)/n(-NCO)、DHPDMS的质量分数,淀粉质量分数对PDMS-PU/ST复合微球的球形、力学强度和降解率的影响。并通过扫描电子显微镜(SEM)和傅立叶变换红外光谱(FT-IR)对微球的表面形态和化学结构进行表征,SEM照片显示复合微球表面光滑且内部有很多致密的管状孔隙,适合用作药物释放载体材料;FT-IR表明硅氧键引入到PU中,且PU和ST之间通过氢键复合。The favorable PDMS-PU/ST complex microspheres were obtained for drug controlled delivery system. First PU anionic solution was synthesized by the prepolymerization,chain extension,neutralization and dispersion method. Subsequently PU solution and ST solution were completely mixed by the volume ratio, and PDMS-PU/ST complex micro- spheres were prepared according to the principles of condensed phase separation. A series of microparticles were prepared with different molecular weight of PEG, different -NCO/-ON ratio,I）HPDMS contents and starch contents to investigate PDMS-PU/ST microspheres morphology, mechanical strength and degradation rate. PU microparticles were characterized by SEM and FTIR spectroscopy to study its structural morphology and chemical constitution. SEM results showed that the microspheres were smooth sphericity whose internal distributed many uniform, compact and radiation liked tubular pores, the structure was conductive to carrying drugs. FT-IR indicated the existent of Si-O-Si, and PU and ST made interaction through hydrogen bond.

关 键 词：聚氨酯 淀粉 聚二甲基硅氧烷 复合微球 

分 类 号：TQ317[化学工程—高聚物工业]