MAG和MA方案治疗老年急性髓系白血病的比较观察  

Comparative observation of MAG and MA regimens on elderly acute myeloid leukemia

作　　者：李林[1] 贺艳娟[1] 蒋端凤 梁英[1] 吴登蜀[1] 祝焱[1] 何群[1] 李晓林[1] 

机构地区：[1]中南大学湘雅医院血液科,湖南长沙410008 [2]桂林医学院附属医院血液科,广西桂林541001

出　　处：《中国现代医学杂志》2014年第15期83-85,共3页China Journal of Modern Medicine

摘　　要：目的比较MAG和MA方案治疗老年急性髓系白血病的疗效和不良反应。方法共有老年急性髓系白血病患者30例,其中14例接受MAG方案化疗,16例接受MA方案化疗。结果 MAG和MA方案的完全缓解率分别为36%、31%,总有效率分别为72%、69%,差异无统计学意义(P>0.05)。不良反应,MAG组较MA组骨髓抑制期短、发生出血及感染情况少(P<0.05),两组化疗方案其他不良反应无显著性差异(P>0.05)。结论对于老年急性髓系白血病患者,MAG方案安全有效,值得临床推广。[ Objective ] To compare the efficacy and adverse effect of MAG with MA regimen in the treatment ofelderly acute myeloid leukemia. [ Methods ] 30 elderly patients with acute myeloid leukemia were enrolled into thisstudy. 14 patients were administered with MAG regimen; 16 patients were administered with MA regimen. [Results ]The complete remission rate was 36% and 31% in MAG and MA-treated group, totally response rate was 72% and69%. There was no significant difference between MAG and MA group （P 〉0.05）. The MAG group had shorter bonemarrow depression and less bleeding, infection occurring （P 〈0.05）. The incidence rates of other toxicities in the twogroups were not significantly different （P 〉0.05）. [ Conclusions ] MAG regimen is effective and safe in treating elderly patients with acute myeloid leukemia, which should be suggested in clinical experiences.

关 键 词：MAG方案 MA方案 老年 急性髓系白血病 

分 类 号：R733.71[医药卫生—肿瘤]