高凝状态对宫颈癌患者复发风险的预测价值  

Prognostic Significance of Coagulation Parameters in Patients with Cervical Cancer

作　　者：赵可雷[1] 叶金辉[2] 吴军[1] 张维维[1] 梁卫江[1] 

机构地区：[1]南方医科大学南方医院肿瘤科,广州市510515 [2]广东省肇庆市第一人民医院肿瘤科,526020

出　　处：《实用医学杂志》2014年第12期1941-1943,共3页The Journal of Practical Medicine

基　　金：广东省自然科学基金(编号:S2013010016194)

摘　　要：目的:分析宫颈癌患者凝血指标的临床特点,评估凝血指标在预测宫颈癌复发风险中的价值。方法:收集本院321例宫颈癌患者治疗前凝血及血小板指标,比较不同分期患者凝血指标的特征,探讨高凝状态与肿瘤复发之间的关系。结果:宫颈癌患者的纤维蛋白原(Fgb)、血小板(PLT)水平随着肿瘤分期的升高而增高(P<0.05)。生存分析显示PTA、Fgb、PLT异常升高患者5年无病生存率(DFS)显著降低(P<0.05),Cox生存分析示分期、PTA、Fgb为宫颈癌的独立预后因素。结论:凝血功能检查可作为预测宫颈癌复发的有效辅助手段。Objective To assess the prognostic significance of pre-treatment hypercoagulable state in cervical cancer patients. Methods With retrospective analysis, pre-treatment coagulation indicators and platelets from 321 cervical cancer patients from stages Ⅰto Ⅴ were collected. The pre-treatment coagulation parameters were investigated along with tumor stage and survival data. Result Advanced tumor stage was associated with elevated fibrinogen （Fbg） and platelet （PLT） levels （P 〈 0.05）. Patients with higher levels of Fgb, PTA and PLT suffered from higher risk of recurrence （P 〈 0.05）. Multivariate survival analyses showed that tumor stage, Fgb and PTA were independent prognostic factors for disease free survival. Conclusion Coagulation parameters can be served as useful tool for predicting recurrence of cervical cancer.

关 键 词：宫颈肿瘤 高凝状态 肿瘤复发 

分 类 号：R737.33[医药卫生—肿瘤]