利培酮和氯丙嗪治疗精神分裂症的比较研究  

Comparative study of risperidoneand chlorpromazine in treatment of schizophrenia

作　　者：梅安昌 张西林[2] 李怀滨 夏守翠 吴维[2] 

机构地区：[1]蚌埠市第一人民医院,安徽蚌埠233000 [2]安徽省荣军医院

出　　处：《中国民康医学》2014年第9期18-20,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:通过与氯丙嗪的对照,探讨利培酮治疗精神分裂症的疗效和不良反应。方法:将122例符合ICD-10诊断标准的精神分裂症患者随机分为两组,分别给予利培酮和氯丙嗪治疗8周。采用阳性症状和阴性症状量表(PANSS)评定临床疗效,副反应量表(TESS)评定不良反应。结果:治疗8周后患者的疗效没有明显差异(P>0.05);利培酮组和氯丙嗪组的显效率差异无统计学意义(P>0.05);氯丙嗪较利培酮组引起患者肌强直、震颤、扭转痉挛、静坐不能等椎体外系的不良反应发生率高,引起胆碱能系统不良反应:口干、视物模糊、便秘、鼻塞发生率高(P<0.05﹚;利培酮对血糖、血脂影响较氯丙嗪小(P<0.05)。结论:利培酮和氯丙嗪治疗精神分裂症疗效相当,利培酮起效快、耐受性好,不良反应小、依从性高。Objective：To explore efficacy and side effects of risperidonein treatment of schizophrenia through comparing with chlorpromazine. Methods：According to the criteria of ICD-10 for schizophrenia,122 patients were randomly divided into two groups. One group was treated by risperidonefor 8 weeks and the other group was treated by chlorpromazine for 8 weeks. The positive and negative symptom scale（PANSS）and treatment emergent symptom scale（TESS）were used to assess the clinical efficacy and side effects in the study. Results：There was no significant difference between risperidonegroup and chlorpromazine group in the treatment of schizophreniaafter 8 weeks′ treatment in the efficacy and obvious effective rate（both P﹥ 0. 05）. The side effect rates were high in chlorpromazine group in extrapyramidal system and cholinergic system,for examplemyotonia,tremor,torsion spasm,dry mouth,blurred vision, constipation,stuffy nose（P﹤0. 05）. The effects of risperidoneon blood glucose and blood lipid were less than chlorpromazine（P﹤0. 05）. Conclusions：The efficacies of risperidoneand chlorpromazine have no significant difference. Risperidone in the treatment of schizophrenia is fast in the effects,and has a good tolerance,less adverse reactions,and high compliance.

关 键 词：利培酮 氯丙嗪 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]