清除幽门螺杆菌感染在帕金森病治疗中的作用  

Efficacy of anti-helicobacter pylori in treatment of parkinson disease

作　　者：许文芳[1] 陈育华[1] 马博[1] 时鹏[1] 陈齐鸣[1] 屈洪党[1] 

机构地区：[1]安徽省蚌埠医学院第一附属医院神经内科,233004

出　　处：《中华全科医学》2014年第8期1222-1223,1271,共3页Chinese Journal of General Practice

摘　　要：目的观察清除幽门螺杆菌（Hp）感染在帕金森病（PD）治疗中的作用。方法选择60例年龄在40～69岁之间的早期PD患者，病史1～3年，UPDRS评分小于20分，且其血清HP抗体阳性，随机分成2组，对照组30例，男性20人，女性10人，从小剂量开始给予美多芭治疗，每次美多芭0．0625g，每132次，逐渐增加剂量，最高量为每次0．25g，每日3次；观察组30例，男性19人，女性11人，在此基础上加用清除Hp治疗（雷尼替丁0．15g＋阿莫西林1．0g＋克拉霉素0．5g，每天2次，共7d）。采用UPDRS评分量表比较2组患者治疗1个月、3个月后的疗效。结果对照组患者治疗1个月和3个月后UPDRS评分从11．77分别降至9．43分（P〈0．01）和8．73分（P〈0．01），治疗3个月UPDRS评分较治疗1个月UPDRS评分差异无统计学意义（P=0．214）。观察组患者治疗1个月和3个月后UPDRS评分从12．67分别降至10．30分（P〈0．01）和7．77分（P〈0．01），治疗3个月UPDRS评分优于治疗1个月UPDRS评分（P〈0．01）。治疗1个月UPDRS评分观察组较对照组无明显改善（P=0．140）；治疗3个月后UPDRS评分观察组较对照组有明显改善（P=0．018）。结论清除Hp感染可提高治疗PD的疗效。Objective To investigate the therapeutic efficacy of Anti-Helieobaeter Pylori in the treatment of Parkinson disease （ PD ）. Methods Sixty patients with PD in the early stage aged 40-69 years old,with a ease history of 1-3 years, UPDRS score less than 20 points, and sera with H. pylori positive, were randomly divided into two groups. 30 patients in the control group including 20 men and 10 women were given Madopar treatment with small doses,0.0625 g each time, twice a day, and gradually increased the dose, the maximum amount for each 0.25 g, three times a day;30 patients in the observation group including 19 men and 11 women received additional ranitidine ,amoxicillin and elarithromycin based on the control. Unified Parkinson disease rating scale（UPDRS） were used to assess the efficacy in both groups. Results In control group, after the one month of therapy and three months, the UPDRS score decreased from 11.77 to 9.43 （ P 〈 0.01 ） and 8.73 （ P 〈 0.01 ） , respectively. No further improvement was achieved after three months of therapy as compared with that after one month medication（P = 0.214）. In observation group,after one month and three months of therapy, the UPDRS score decreased from 12.67 to 10.30 （P 〈 0.001 ） and 7.77 （P 〈 0.01 ）, respectively. After three months of treat- ment, the UPDRS score showed markedly improved as compared to that after one month of therapy（P 〈 0.01 ）. After one month of therapy, the UPDRS score of observation group showed that no further improvement was achieved than control group （P = 0. 140） ;After three month of therapy, the UPDRS score indicated that the improvement of observation group was better than control group （P = 0. 018 ）. Conclusion Anti-Helicobacter Pylori treatment can improve the therapeutic effect of PD symptoms.

关 键 词：帕金森病 美多巴 幽门螺杆菌 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R738.2[医药卫生—临床医学]