XIAP及survivin在原发性肝细胞癌组织中的表达及其相关性研究  

Study on the Expression and Crrelation of XIAP and Survivin in Primary Hepatocellular Carcinoma (HCC)

作　　者：杨德华 郭晓东[2] 余灵祥[2] 周艳贤[2] 杨美[2] 熊璐[2] 李志伟[2] 

机构地区：[1]成都市公共卫生临床医疗中心,四川成都610066 [2]解放军第302医院,北京100039

出　　处：《现代生物医学进展》2014年第18期3426-3428,共3页Progress in Modern Biomedicine

基　　金：四川省中医药管理局课题(2010-39)

摘　　要：目的:探讨X连锁凋亡抑制蛋白(XIAP)和survivin在原发性肝细胞癌中的表达及两者的相关性。方法:选取本院收治的60例原发性肝细胞癌患者,应用免疫组织化学染色的方法对肝癌组织及癌旁组织中的XIAP及survivin的表达进行检测。结果:经比较,肝癌组织中XAIP及survivin的阳性率均显著高于癌旁组织,差异有统计学意义。XIAP和survivin的表达强度与肿瘤的大小无关,但随肿瘤的分化程度的降低而升高,且不同分化程度之间差异有统计学意义;XIAP和survivin存在正相关关系。结论:XIAP与Survivin在肿瘤组织中的高表达在促进肿瘤发生、增殖、转移以及耐药,并且能够降低肿瘤的分化程度,增加肝癌的恶性程度。此外,两者可能存在协同作用,但两者的相关性及作用机制仍需进一步探讨。Objective： To explore the expression and correlation of XIAP and survivin in primary hepatocellular carcinoma （HCC）. Methods： 60 patients with HCC treated in our hospital were selected, and the expression of XIAP and survivin in HCC tissues and adjacent mucosa were detected by immunohistochemistry staining. Results： Comparatively, the positive rate of XAIP and survivin in HCC tissues were significantly higher than that of adjacent mucosa, the difference was statistically significant. The expression intensity of XIAP and survivin had nothing to do with the tumor size, but it expressed highly with the decrease of differentiation degree of tumor, and the differences between different differentiation degree were statistically significant; positive correlation existed between XIAP and survivin. Conclusion： High expression of XIAP and survivin in tumor tissues can promote the incidence, proliferation, metastasis and drug resistance of tumor, as well as reduce the tumor differentiation degree, increase the malignant grade of liver cancer. In addition, there are possible synergies between XIAP and survivin, but their correlation and mechanism needs further exploration.

关 键 词：原发性肝细胞癌 X连锁凋亡抑制蛋白 SURVIVIN 相关性 

分 类 号：R735.7[医药卫生—肿瘤] R365[医药卫生—临床医学]