认知障碍初步评价表在中重度阿尔茨海默病中的初步应用  

Preliminary evaulation of Cognitive-12 in moderate and severe Alzheimer's disease

作　　者：梅刚[1] 陆蓉[1] 徐俊[2,3] 郑丽梅[1] 李海林[1] 

机构地区：[1]南京医科大学附属脑科医院老年精神科,江苏南京210029 [2]南京医科大学附属江苏省老年医院神经内科 [3]江苏省老年医学研究所,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2014年第5期637-640,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81271211;30700248);科技部重大新药创制(2012ZX09303005-002);国家临床重点专科建设项目;江苏省医学重点学科;江苏省神经退行性疾病重点实验室开放课题(SJ11KF05);江苏省卫生厅预防医学课题(YZ201022);江苏省科技支撑计划(社会发展)项目(BE2011614)

摘　　要：目的 :探讨认知障碍初步评价表(cognitive-12,COG-12)区分中、重度度阿尔茨海默病(Alzheime’s disease,AD)的能力。方法:61例中度和55例重度阿尔茨海默病患者为研究对象,对所有对象进行COG-12、AD8、MMSE及CDR测试。结果:重度AD患者COG-12、AD8、MMSE总分明显高于中度AD。多元回归分析提示COG-12评分不受被试者年龄及受教育年限的影响。COG-12能有效区分中、重度AD,敏感度为90.9%,特异度为70.5%。结论:COG-12对中、重度AD具有较好的区分能力。Objective：To examine the discriminatory potential of the Cognitive-12 for moderate and severe Alzheimer＇s disease（AD）. Methods：Patients with AD（61 moderate AD and 55 severe AD） were recruited. The COG-12,AD8,MMSE and CDR were tested by all AD subjects. Results：The total scores of COG-12,AD8,MMSE and CDR differed significantly between moderate and severe AD groups with higher scores in severe AD group. The results of multiple linear regression analysis showed insignificant influence of age or educational level on the COG-12 total score. COG-12 could classify moderate and severe AD efficiently with sensitivity of 90.9% and specificity of 70.5%. Conclusion：COG-12 is useful for staging of moderate and severe AD.

关 键 词：阿尔茨海默病 认知障碍初步评价表 量表 

分 类 号：R749.16[医药卫生—神经病学与精神病学]